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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Valsartan
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Valsartan" in MCE Product Catalog:
24
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Research Areas:
Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .
10
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Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure . Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis .
2
2 Cited Publications
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Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure .
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Devaleryl Valsartan Impurity is an intermediate in the synthesis of Valsartan .
Cat. No.: HY-W414915
CAS No.: 137863-17-3
Synonyms: CGP 48933 methyl ester
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Research Areas:
Valsartan (CGP 48933) methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective and orally active angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure .
Cat. No.: HY-18204S2
CAS No.: 1089736-72-0
Synonyms: CGP 48933-d8
Cat. No.: HY-18204S
CAS No.: 1089736-73-1
Synonyms: CGP 48933-d9
Cat. No.: HY-18204S1
CAS No.: 1331908-02-1
Synonyms: CGP 48933-d3
Cat. No.: HY-Z0061
CAS No.: 137863-20-8
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Valsartan benzyl ester is an intermediate of Valsartan (HY-18204). Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .
Cat. No.: HY-78847
CAS No.: 761373-05-1
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2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
Cat. No.: HY-18204R
CAS No.: 137862-53-4
Synonyms: CGP 48933 (Standard)
Research Areas:
Valsartan (Standard) is the analytical standard of Valsartan. This product is intended for research and analytical applications. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .
Cat. No.: HY-78846
CAS No.: 2259708-00-2
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2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
Cat. No.: HY-Z0081
CAS No.: 2307668-79-5
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2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
Cat. No.: HY-I1208
CAS No.: 137862-87-4
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D-Valsartan is an impurity of Valsartan (HY-18204). Valsartan is an angiotensin II (angiotensin II) receptor antagonist .
Cat. No.: HY-W414915R
CAS No.: 137863-17-3
Synonyms: CGP 48933 methyl ester (Standard)
Research Areas:
Valsartan (CGP 48933) methyl ester (Standard) is the analytical standard of Valsartan methyl ester (HY-W414915). This product is intended for research and analytical applications. Valsartan methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure .
Cat. No.: HY-W699533
CAS No.: 188259-69-0
Synonyms: Valeryl-4-hydroxyValsartan; CGP 71580
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4-Hydroxy valsartan is a metabolite of Valsartan (HY-18204). 4-Hydroxy valsartan regulates the expression of platelet surface receptors and inhibits conventional plasma or whole blood collagen induced platelet aggregation. 4-Hydroxy valsartan has antiplatelet activity .
Cat. No.: HY-18204S3
Synonyms: (Rac)-CGP 48933-d9
Cat. No.: HY-131280R
CAS No.: 676129-92-3
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L-Aspartyl-L-phenylalanine (Standard) is the analytical standard of L-Aspartyl-L-phenylalanine. This product is intended for research and analytical applications. L-Aspartyl-L-phenylalanine is a metabolite of aspartame that can inhibit angiotensin converting enzyme (ACE) purified from rabbit lungs with a Ki of 11 μM .
Cat. No.: HY-Z0075
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(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
Cat. No.: HY-78847R
CAS No.: 761373-05-1
Target:
Research Areas:
2R,4S-Sacubitril (Standard) is the analytical standard of 2R,4S-Sacubitril. This product is intended for research and analytical applications. 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
