Valsartan benzyl ester
Based on 1 Customer Validation
Valsartan benzyl ester is an intermediate of Valsartan (HY-18204). Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
For research use only. We do not sell to patients.
- Purity: 98.37%
- CAS No.: 137863-20-8
- Formula: C31H35N5O3
- Molecular Weight:525.64
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 137863-20-8
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Appearance Solid
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Molecular Weight 525.64
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Formula C31H35N5O3
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Color White to off-white
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SMILES
O=C(OCC1=CC=CC=C1)[C@H](C(C)C)N(C(CCCC)=O)CC2=CC=C(C=C2)C3=C(C4=NN=NN4)C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (190.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.76 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9024 mL | 9.5122 mL | 19.0244 mL | 47.5611 mL |
| 5 mM | 0.3805 mL | 1.9024 mL | 3.8049 mL | 9.5122 mL | |
| 10 mM | 0.1902 mL | 0.9512 mL | 1.9024 mL | 4.7561 mL | |
| 15 mM | 0.1268 mL | 0.6341 mL | 1.2683 mL | 3.1707 mL | |
| 20 mM | 0.0951 mL | 0.4756 mL | 0.9512 mL | 2.3781 mL | |
| 25 mM | 0.0761 mL | 0.3805 mL | 0.7610 mL | 1.9024 mL | |
| 30 mM | 0.0634 mL | 0.3171 mL | 0.6341 mL | 1.5854 mL | |
| 40 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1890 mL | |
| 50 mM | 0.0380 mL | 0.1902 mL | 0.3805 mL | 0.9512 mL | |
| 60 mM | 0.0317 mL | 0.1585 mL | 0.3171 mL | 0.7927 mL | |
| 80 mM | 0.0238 mL | 0.1189 mL | 0.2378 mL | 0.5945 mL | |
| 100 mM | 0.0190 mL | 0.0951 mL | 0.1902 mL | 0.4756 mL |
Valsartan benzyl ester Related Classifications
HY-Z0061 Related Classifications
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