1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Valsartan D9

Valsartan D9 (Synonyms: CGP 48933 D9)

Cat. No.: HY-18204S Purity: ≥99.0%
Handling Instructions

Valsartan D9 (CGP-48933 D9) is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.

For research use only. We do not sell to patients.

Valsartan D9 Chemical Structure

Valsartan D9 Chemical Structure

CAS No. : 1089736-73-1

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Description

Valsartan D9 (CGP-48933 D9) is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

In Vitro

Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

444.57

Formula

C₂₄H₂₀D₉N₅O₃

CAS No.

1089736-73-1

SMILES

CC(C)[[email protected]@H](C(O)=O)N(C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)CC(C=C1)=CC=C1C2=CC=CC=C2C3=NN=NN3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
Animal Administration
[4]

Rats: Rats are randomly divided into two groups: (i) valsartan-treated group that is given intravenously 3 mg/kg/day valsartan in 0.5 mL normal saline via the vein daily for 1 week; (ii) hydralazine-treated group receiving 0.2 mg/kg/day hydralazine injection in saline; and (iii) control group that receives saline injection in the same way (n=15 for each group)[4].

Mice: Valsartan is dissolved in water containing 0.5% methylcellulose solution. Valsartan (5-40 mg/kg/d) is administered by oral (p.o.) route in a volume of 10 mL/kg body weight using the gavage technique. Potential alteration in blood pressure in response to chronic treatment with valsartan is assessed with a commercial blood pressure analysis systemdesigned. The mice are trained for at least 2 consecutive days to adapt to the apparatus before the study is initiated. To record the blood pressure, the mice are placed on a heated pad (35°C) and measured with a programmable tail-cuff sphygmomanometer in steady state. The average of 10 readings from each mouse is recorded[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Valsartan D9CGP 48933 D9Valsartan D 9Valsartan D-9Angiotensin ReceptorInhibitorinhibitorinhibit

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Valsartan D9
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HY-18204S
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