2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 2R,4S-Sacubitril

2R,4S-Sacubitril 

Cat. No.: HY-78847 Purity: 97.16%
COA Handling Instructions

2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

For research use only. We do not sell to patients.

2R,4S-Sacubitril Chemical Structure

2R,4S-Sacubitril Chemical Structure

CAS No. : 761373-05-1

Size Price Stock Quantity
1 mg USD 110 In-stock
5 mg USD 330 In-stock
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50 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2R,4S-Sacubitril:

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Description

2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

Molecular Weight

411.49

Appearance

Oil

Formula

C24H29NO5
CAS No.
SMILES

[H]N(C(CCC(O)=O)=O)[[email protected]@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[[email protected]@H](C(OCC)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4302 mL 12.1510 mL 24.3019 mL
5 mM 0.4860 mL 2.4302 mL 4.8604 mL
10 mM 0.2430 mL 1.2151 mL 2.4302 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.08 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2R,4S-Sacubitril761373-05-1Drug MetaboliteInhibitorinhibitorinhibit

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