40 Results for "

Withanolides

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "Withanolides" in MCE Product Catalog:

1
2,3-Didehydrosomnifericin
2,3-Didehydrosomnifericin
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1 Cited Publications
Cat. No.: HY-N5069
CAS No.: 173614-88-5
Category:  

other families Other Diseases Plants Disease Research Fields Steroids

Target:  

Bacterial

2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .
1
Physalin A
Physalin A
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1 Cited Publications
Cat. No.: HY-N9942
CAS No.: 23027-91-0
Category:  

Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Ketones, Aldehydes, Acids Plants Solanaceae Disease Research Fields Cancer

Target:  

Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK

Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .
Withanolide A
Withanolide A
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Cat. No.: HY-N7028
CAS No.: 32911-62-9
Category:  

other families Neurological Disease Anti-aging Plants Disease Research Fields Steroids

Target:  

Notch Apoptosis

Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases .
Sominone
Sominone
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Cat. No.: HY-N10889
CAS No.: 98569-64-3
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

Drug Metabolite RET

Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .
Withanolide B
Withanolide B
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Cat. No.: HY-129566
CAS No.: 56973-41-2
Pureté:  98.52%
Category:  

Neurological Disease Metabolic Disease Withania somnifera Plants Solanaceae Disease Research Fields Inflammation/Immunology Steroids

Target:  

ERK Wnt β-catenin RUNX

Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .
Withaphysalin A
Withaphysalin A
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Cat. No.: HY-N11011
CAS No.: 57423-72-0
Category:  

Physalis minima Linn. Plants Solanaceae Steroids

Target:  

NF-κB STAT PERK JNK p38 MAPK PGE synthase Interleukin Related TNF Receptor COX

Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE2, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia .
Dihydrowithaferin A
Dihydrowithaferin A
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Cat. No.: HY-N5120
CAS No.: 5589-41-3
Synonyms: 2,3-Dihydrowithaferin A
Category:  

Withania somnifera Plants Solanaceae Disease Research Fields Cancer Steroids

Target:  

Cholinesterase (ChE)

Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .
Withanoside V
Withanoside V
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Cat. No.: HY-N8671
CAS No.: 256520-90-8
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

Amyloid-β Apoptosis Reactive Oxygen Species (ROS) SARS-CoV

Withanoside V is a blood-brain barrier-permeable withanolide derivative . Withanoside V binds strongly to Sudlow I (domain IIA) of human serum albumin (HSA) to form a stable complex and alter the secondary structure of albumin, thereby increasing helix content and reducing β-sheet and random coil. Withanoside V binds to Aβ (1-42) to block the interaction between monomers and subsequent aggregation. Withanoside V inhibits the viability of neuroblastoma cells, reduces the number of apoptotic cells induced by Aβ (1-42), and decreases ROS production. Withanoside V inhibits SARS-CoV-2 Mpro. Withanoside V can be used for research on Alzheimer's disease and coronavirus disease 2019 .
Mp-4D7-pF2
Mp-4D7-pF2
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Cat. No.: HY-P11032
CAS No.: 3106022-48-1
Target:  

SARS-CoV Virus Protease

Domaines de recherche:  

Infection

Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC50 of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .
Withanolide S
Withanolide S
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Cat. No.: HY-N9061
CAS No.: 63139-16-2
Category:  

Plants Solanaceae Steroids

Target:  

Others

Withanolide S is isolated from the natural Physalis cinerascens .
3β-Methoxy-2,3-dihydrowithaferin A
3β-Methoxy-2,3-dihydrowithaferin A
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Cat. No.: HY-N5131
CAS No.: 73365-94-3
Synonyms: Quresimin A
Category:  

other families Other Diseases Plants Disease Research Fields Steroids

Target:  

Others

3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .
Withanolide A (Standard)
Withanolide A (Standard)
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Cat. No.: HY-N7028R
CAS No.: 32911-62-9
Category:  

Natural Products other families Plants Steroids

Target:  

Reference Standards Notch Apoptosis

Withanolide A (Standard) is the analytical standard of Withanolide A. This product is intended for research and analytical applications. Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases .
Chantriolide B
Chantriolide B
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Cat. No.: HY-N16626
CAS No.: 558470-60-3
Category:  

Plants Tacca chantrieri Andre Taccaceae Saccharides Monosaccharides

Target:  

Others

Chantriolide B is a new withanolide glucoside. Chantriolide B can be isolated from the rhizomes of Tacca chantrieri. Chantriolide B does not inhibit NO in cells .
Withanoside IV
Withanoside IV
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Cat. No.: HY-N8693
CAS No.: 362472-81-9
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

COX Amyloid-β Sirtuin Reactive Oxygen Species (ROS) Apoptosis SARS-CoV

Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19) .
Withasomniferolide A
Withasomniferolide A
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Cat. No.: HY-N10884
CAS No.: 2365386-74-7
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

Others

Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .
6α-Chloro-5β-hydroxywithaferin A
6α-Chloro-5β-hydroxywithaferin A
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Cat. No.: HY-N5113
CAS No.: 52329-20-1
Category:  

Other Diseases Withania somnifera Plants Solanaceae Disease Research Fields Steroids

Target:  

Bacterial

6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .
Withasomniferolide B
Withasomniferolide B
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Cat. No.: HY-N10887
CAS No.: 2365386-75-8
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

GABA Receptor

Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .
4,27-Dimethyl withaferin A
4,27-Dimethyl withaferin A
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Cat. No.: HY-N10356
CAS No.: 1777780-95-6
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

Others

4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .
4-Dehydrowithaferin A
4-Dehydrowithaferin A
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Cat. No.: HY-138146
CAS No.: 6850-30-2
Synonyms: 4-oxo Withaferin A
Category:  

Quinones Withania somnifera Benzene Quinones Plants Solanaceae Disease Research Fields Cancer

Target:  

Drug Derivative

4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .
Withanoside V (Standard)
Withanoside V (Standard)
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Cat. No.: HY-N8671R
CAS No.: 256520-90-8
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

Reference Standards Others

Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .
Assay Types