98569-64-3
Chemical Structure
Sominone
- CAS No.: 98569-64-3
- Formula:C28H42O5
- Molecular Weight:458.63
IUPAC Name: (R)-6-((S)-1-((1S,3R,8S,9S,10R,13S,14S,17R)-1,3-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl)-3-(hydroxymethyl)-4-methyl-5,6-dihydro-2H-pyran-2-one
InChIKey: FYYIHVSEGVWNCF-RMDUJBCISA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](C[C@@H]2O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H]([C@@]5([H])CC(C)=C(C(O5)=O)CO)C)C
Biological Activity: Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sominone | 99.96% | Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Kuboyama T, et al. Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration. Eur J Neurosci. 2006 Mar;23(6):1417-26. [Content Brief]
- [2]. Tohda C, et al. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. Br J Pharmacol. 2009 Aug;157(8):1427-40. [Content Brief]
- [3]. Joyashiki E, et al. Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD. Int J Neurosci. 2011 Apr;121(4):181-90. [Content Brief]
Keywords
