98569-64-3
Chemical Structure
Sominone
- CAS No.: 98569-64-3
- Formula:C28H42O5
- Molecular Weight:458.63
IUPAC Name: (R)-6-((S)-1-((1S,3R,8S,9S,10R,13S,14S,17R)-1,3-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl)-3-(hydroxymethyl)-4-methyl-5,6-dihydro-2H-pyran-2-one
InChIKey: FYYIHVSEGVWNCF-RMDUJBCISA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](C[C@@H]2O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H]([C@@]5([H])CC(C)=C(C(O5)=O)CO)C)C
Biological Activity: Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Sominone | 99.96% | Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2,3-Dihydro-3-methoxywithaferin A | 98.78% | 2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4-epi-Withaferin A | 4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Withasomniferolide A | Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Viscosalactone B | Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC50 values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Somnifericin | Somnifericin is a natural product. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Withaferin A | 99.71% | Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Daturataturin A aglycone | Daturataturin A aglycone is a natural steroid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2,3-Didehydrosomnifericin | 99.13% | 2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dihydrowithaferin A | 99.72% | Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3β-Methoxy-2,3-dihydrowithaferin A | 99.83% | 3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Kuboyama T, et al. Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration. Eur J Neurosci. 2006 Mar;23(6):1417-26. [Content Brief]
- [2]. Tohda C, et al. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. Br J Pharmacol. 2009 Aug;157(8):1427-40. [Content Brief]
- [3]. Joyashiki E, et al. Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD. Int J Neurosci. 2011 Apr;121(4):181-90. [Content Brief]
