23027-91-0
Chemical Structure
Physalin A
- CAS 番号: 23027-91-0
- Formula:C28H30O10
- Molecular Weight:526.53
InChIKey: VELDODQHYQSJOF-RPKVKFPNSA-N
SMILES: C[C@@]([C@@](OC1=O)([H])C2)(OC3=O)[C@@]([C@@]3(CC[C@@]([C@]45C)([H])[C@@]6([H])[C@@H](C=C4CC=CC5=O)O)O)(O[C@@]76O)[C@](C7=O)([H])[C@]2(C1=C)C
Biological Activity: Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc[1][2][3][4].
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Physalin A | 99.63% | Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc. | ||||||||||||||||||||
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- [1]. Shin JM, et al. Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes. BMC Complement Altern Med. 2019 May 9;19(1):101. [Content Brief]
- [2]. Kang N, et al. Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway. Mol Cell Biochem. 2016 Apr;415(1-2):145-55. [Content Brief]
- [3]. Zhu F, et al. Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling. Oncotarget. 2016 Feb 23;7(8):9462-76. [Content Brief]
- [4]. Lu R, et al. Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects. J Orthop Translat. 2023 Jan 25;39:74-87. [Content Brief]
Keywords
