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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
ZBP-1
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "ZBP-1" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-N0417
CAS No.: 18444-66-1
Synonyms: α-Elaterin; α-Elaterine
Target:
1
Cat. No.: HY-N2397
CAS No.: 1167424-31-8
Synonyms: MSB
Category:
Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Metabolic Disease Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields
Target:
Cat. No.: HY-177119
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Research Areas:
ZBP1 Covalent PROTAC-1 is a covalent Z-DNA binding protein 1 ZBP1 PROTAC degrader, with its DC50 being 25.69 nM. ZBP1 Covalent PROTAC-1 integrates the ligand that recruits the VHL E3 ubiquitin ligase and the DNA aptamer (Aptamer Z3) with the specific Zα domain that can bind to ZBP1, which has a high affinity (KD = 2.71 nM) with ZBP1. After degrading ZBP1, the phosphorylation levels of downstream signaling molecules RIPK3 and MLKL significantly decrease. ZBP1 Covalent PROTAC-1, encapsulated by nano-liposomes, significantly improves the survival rate of mice infected with influenza A virus (IAV) after administration via the trachea [1].
Cat. No.: HY-RS15958
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ZBP1 Human Pre-designed siRNA Set A contains three designed siRNAs for ZBP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-162424
CAS No.: 3057611-79-4
Research Areas:
ZBP1/RIP3/MLKL activator 1 (compound 3a) is a synthetically derived quinoline compound. ZBP1/RIP3/MLKL Activator 1 induces DNA damage, enhances intracellular levels of reactive oxygen species (ROS), and triggers apoptosis via the caspase pathway. Furthermore, when apoptosis is inhibited, ZBP1/RIP3/MLKL Activator 1 promotes necroptotic cell death through the ZBP1-RIP3-MLKL pathway. ZBP1/RIP3/MLKL Activator 1 is utilized in oncological research, particularly in the selective targeting of cells with impaired apoptotic function [1].
Cat. No.: HY-RS16687
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Zbp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Zbp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06619
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IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23122
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Zbp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Zbp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-185102
ZBP1 PROTAC-1 (2a+aptamer) is a Z-DNA binding protein 1 (ZBP1) PROTAC. ZBP1 PROTAC-1 consists of a DNA aptamer (specifically binds to ZBP1) and an E3 enzyme-recruiting unit. ZBP1 PROTAC-1 combines the high specificity of DNA aptamers with the degradation-inducing capabilities of PROTACs, providing a powerful tool for targeted protein degradation [1].
Cat. No.: HY-P704184
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DNA-dependent activator of IFN-regulatory factors; DAI; Tumor stroma and activated macrophage protein DLM-1; ZBP1
Cat. No.: HY-RS23290
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Igf2bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P7S2794
Purity: ≥ 90%, as determined by reducing SDS-PAGE .
Synonyms: Insulin-like growth factor 2 mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; IMP1; Coding region determinant-binding protein (CRD-BP); IGF-II mRNA-binding protein 1; VICKZ family member 1; Zipcode-binding protein 1 (ZBP-1); IGF2BP1; CRDBP; VICKZ1; ZBP1
Cat. No.: HY-P704188
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DNA-dependent activator of IFN-regulatory factors; DAI; Tumor stroma and activated macrophage protein DLM-1
Cat. No.: HY-181129
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ADAR1i-124 is an A-to-I RNA editing inhibitor by inhibiting the catalytic activities of both ADAR1p150 and ADAR1p110. ADAR1i-124 activates type I interferon (IFN) and ZBP1 pathways and dose-dependently inhibits viability across different types of cancer cell lines. ADAR1i-124 can induce cells apoptosis and necroptosis. ADAR1i-124 can be used for the research of cancer, such as cutaneous melanoma and ovarian cancer [1].
Cat. No.: HY-181850
CAS No.: 3094716-52-3
Research Areas:
Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC50 of 0.4 μM. Telomeric G4s ligand 2 binds to dimeric telomeric G4, inhibits the activities of DHX36 and BLM helicases. Telomeric G4s ligand 2 activates cGAS-STING and TERRA-ZBP1 pathways, inducing autophagy and G2/M cell cycle arrest, and exhibits antiproliferative effects across cancer cell lines. Telomeric G4s ligand 2 can be used for the study of colorectal cancer [1].
Cat. No.: HY-RS16849
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Igf2bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
