3094716-52-3
Chemical Structure
Telomeric G4s ligand 2
- CAS No.: 3094716-52-3
- Formula:C25H32N6O
- Molecular Weight:432.56
InChIKey: UNCPRPOWSLTXOD-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(NC2=NC(N3CCCC3)=NC4=CC=CC=C42)C=C1)CCN(CC)CC
Biological Activity: Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC50 of 0.4 μM. Telomeric G4s ligand 2 binds to dimeric telomeric G4, inhibits the activities of DHX36 and BLM helicases. Telomeric G4s ligand 2 activates cGAS-STING and TERRA-ZBP1 pathways, inducing autophagy and G2/M cell cycle arrest, and exhibits antiproliferative effects across cancer cell lines. Telomeric G4s ligand 2 can be used for the study of colorectal cancer[1].
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Telomeric G4s ligand 2 | Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC50 of 0.4 μM. Telomeric G4s ligand 2 binds to dimeric telomeric G4, inhibits the activities of DHX36 and BLM helicases. Telomeric G4s ligand 2 activates cGAS-STING and TERRA-ZBP1 pathways, inducing autophagy and G2/M cell cycle arrest, and exhibits antiproliferative effects across cancer cell lines. Telomeric G4s ligand 2 can be used for the study of colorectal cancer. | |||||||||||||||||||||
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Keywords
