8 Results for "

arenes

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "arenes" in MCE Product Catalog:

Cat. No.: HY-W013053
CAS No.: 53-70-3
Synonyms: DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene
Dibenz[a,h]anthracene (DBA) is an orally active polycyclic aromatic hydrocarbon, a by-product of incomplete combustion of organic matter, a potent carcinogen, and an agonist of AhR. Dibenz[a,h]anthracene induces dose-dependent increases in DNA adduct formation and lacZ mutation frequency. Dibenz[a,h]anthracene upregulates St3gal5. Dibenz[a,h]anthracene can be used in cancer-related research .
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Cat. No.: HY-I0101
CAS No.: 60705-62-6
Synonyms: Tetra-tert-butyl(tetrahydroxy)calix[4]arene
Target:  

Drug Intermediate

Research Areas:  

Others

4-tert-Butylcalix[4]arene (Tetra-tert-butyl(tetrahydroxy)calix[4]arene) is a drug intermediate for synthesis of various active compounds.
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Cat. No.: HY-19094
CAS No.: 124750-95-4
Target:  

Angiotensin Receptor

Research Areas:  

Cardiovascular Disease

DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction .
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Cat. No.: HY-Y1094
CAS No.: 12092-47-6
Synonyms: Chloro(1,5-cyclooctadiene)rhodium(I) dimer
Research Areas:  

Cardiovascular Disease Cancer

[Rh(cod)Cl]2 (Chloro (1,5-cyclooctadiene) rhodium (I) dimer) is an organometallic rhodium (I) dimer precursor and platelet aggregation inhibitor. [Rh(cod)Cl]2 inhibits PAF-induced aggregation in washed rabbit platelets. [Rh(cod)Cl]2 inhibits aggregation induced by PAF, Thrombin, ADP and Collagen in human platelet-rich plasma. [Rh(cod)Cl]2 acts as a catalyst precursor for the hydrogenation of aromatic hydrocarbons, phenols, olefins and BINOL derivatives. [Rh(cod)Cl]2 is used in the research of cardiovascular diseases such as thromboinflammation-related disorders, tumor metastasis and atherosclerosis .
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Cat. No.: HY-W440555
CAS No.: 112269-92-8
Synonyms: para-Sulfonatocalix[n]arene
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

4-Sulfocalix[4]arene (para-Sulfonatocalix[n]arene) is a amyloid-beta 42 binder with a Kd of 5.39 M. 4-Sulfocalix[4]arene can inhibit amyloid β-peptide fibrillation and reduce amyloid cytotoxicity .
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Cat. No.: HY-W440556
CAS No.: 137407-62-6
Synonyms: 4-Sulfocalix[8]arene
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

GL-522 (4-Sulfocalix[8]arene) is a Aβ42 inhibitor. GL-522 bind to Aβ42 through nonspecific and multipoint hydrophobic interactions with a Kd of 276  μM. GL-522 effectively inhibits Aβ42 fibrillation and reduces amyloid cytotoxicity. GL-522 can be used for Alzheimer's disease research .
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Cat. No.: HY-12491
CAS No.: 691388-62-2
Target:  

PI3K Apoptosis

Research Areas:  

Cancer

PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma .
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Cat. No.: HY-W096907
CAS No.: 213-46-7
Research Areas:  

Cancer

Picene is a polycyclic aromatic hydrocarbon of environmental relevance. Picene can be widely distributed in the environment as the result of incomplete combustion of organic matter. Picene is found to be inactive as complete carcinogen, while it acts in a high dose as a weak tumor initiator .
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