691388-62-2
Chemical Structure
PIK-C98
- CAS No.: 691388-62-2
- Formula:C16H10Cl2N2OS
- Molecular Weight:349.23
IUPAC Name: (2E,4E)-2-cyano-5-(5-(2,5-dichlorophenyl)furan-2-yl)penta-2,4-dienethioamide
InChIKey: CGTZIMSTGBXOIG-IGAJHJTCSA-N
SMILES: N#C/C(C(N)=S)=C\C=C\C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1
Biological Activity: PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].
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PIK-C98 | PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma. | |||||||||||||||||||||
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Keywords
