13 Results for "

chimeric viruses

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "chimeric viruses" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99832
CAS No.: 1792982-57-0
Synonyms: c13C6-FR1

Target:  

Filovirus

Research Areas:  

Infection

Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP) .
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Cat. No.: HY-P991200

Target:  

HCV Claudin

Research Areas:  

Infection

OM-7D3-B3 is an antibody-based antiviral agent targeting the tight junction protein CLDN1 (Kd=4 nM). By binding to the first extracellular domain of CLDN1, OM-7D3-B3 disrupts the formation of the CLDN1-CD81 co-receptor complex, thereby effectively inhibiting the entry of hepatitis C virus (HCV). OM-7D3-B3 not only prevents de novo and chronic HCV infections in humanized liver chimeric mice and uPA-SCID mice transplanted with human livers, but also exhibits favorable safety with no toxic effects observed. OM-7D3-B3 serves as a critical tool for research on HCV infection mechanisms and antiviral drug development .
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Cat. No.: HY-P4086
CAS No.: 1678417-57-6
Target:  

RABV nAChR

Research Areas:  

Neurological Disease Cancer

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to
nAChR
on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer .
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Cat. No.: HY-P99686
CAS No.: 1792982-56-9
Synonyms: c4G7-N

Target:  

Filovirus

Research Areas:  

Infection

Larcaviximab (c4G7-N) is an IgG1 kappa chimeric monoclonal antibody against Ebola virus glycoprotein, which is applicable to studies related to Ebola virus infection .
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Cat. No.: HY-P990835

Target:  

Integrin

Research Areas:  

Infection Inflammation/Immunology

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) is a kind of mouse IgG1 chimeric antibody inhibitor, targeting to human LFA-1α/CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) reacts with human LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) can be used for the researches of immunology and infection, such as human immunodeficiency virus (HIV) .
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Cat. No.: HY-P990828

Target:  

PD-1/PD-L1

Research Areas:  

Infection

Anti-PD-L1/B7-H1 Antibody (29E.2A3) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human PD-L1/B7-H1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can block the binding of PD-1 to PD-L1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can be used for the research of infection, such as hepatitis C virus (HCV) .
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Cat. No.: HY-P990843

Research Areas:  

Infection

Anti-Glycophorin A (type M) Antibody (6A7M) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human Glycophorin A (type M). Anti-Glycophorin A (type M) reacts with the human glycophorin A (GPA) M allele also known as CD235a. Anti-Glycophorin A (type M) can be used for the research of infection, such as human immunodeficiency virus (HIV) .
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Cat. No.: HY-P990874

Target:  

HIV

Research Areas:  

Infection

Anti-HIV gp120 Antibody (55-36) is a kind of mouse IgG1 κ chimeric antibody, targeting to human HIV gp120. Anti-HIV gp120 Antibody (55-36) reacts with human immunodeficiency virus (HIV) envelope glycoprotein 120 (gp120). Anti-HIV gp120 Antibody (55-36) can be used for the research of HIV infection .
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Cat. No.: HY-P990829

Research Areas:  

Infection

Anti-NKG2D/CD314 Antibody (1D11) is a kind of mouse IgG1 κ chimeric antibody, targeting to human NKG2D/CD314. Anti-NKG2D/CD314 Antibody (1D11) can block the binding of NKG2D to its ligands. Anti-NKG2D/CD314 Antibody (1D11) can be used for the research of infection, such as HIV (human immunodeficiency virus) .
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Cat. No.: HY-P990848

Target:  

CTLA-4

Research Areas:  

Infection Inflammation/Immunology

Anti-CTLA-4/CD152 Antibody (BN13) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human CTLA-4/CD152. Anti-CTLA-4/CD152 Antibody (BN13) can neutralize CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-CTLA-4/CD152 Antibody (BN13) can be used for the researches of infection and immunology, such as human immunodeficiency virus (HIV) .
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Cat. No.: HY-180162
CAS No.: 2781933-70-6
Target:  

Influenza Virus

Research Areas:  

Infection

Influenza A virus-IN-17 (Compound 6a) is a potent influenza A inhibitor with EC90s of 3.5 μM and 2.6 μM for H3N2 and H1N1, respectively. Influenza A virus-IN-17 inhibits U2-PB2 chimeric mRNA (EC90 = 2.1 μM from cap snatching polymerase) .
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Cat. No.: HY-16342
CAS No.: 827034-92-4
NA808 is an Serine Palmitoyltransferase (SPT) inhibitor. NA808 reduces sphingomyelin synthesis, inhibits its activation in hepatic stellate cells, and decreases the expression of α-SMA protein and mRNA, as well as collagen 1A1 mRNA (IC50 0.16, 0.12, and 0.11 μM, respectively). NA808 inhibits HCV replication and reduces NS3 and RdRp protein expression in HCV replicon cells without significant cytotoxicity and exhibits almost no immunosuppressive effect at effective concentrations. NA808 demonstrates broad-spectrum antiviral activity in humanized chimeric liver mice infected with various HCV genotypes, and dose-dependently reduces serum and hepatic HCV RNA levels. NA808 can be used for research on non-alcoholic steatohepatitis and hepatitis C virus infection .
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Cat. No.: HY-P11137
CAS No.: 878495-58-0
Target:  

HSV

Research Areas:  

Cancer

LANA is a KSHV latency-associated nuclear antigen. The core function of LANA is to act as an "anchor" for the viral genome, attaching it to the chromatin of the host cell. LANA ensures that the episomal DNA of KSHV replicates together with the host chromosome and is evenly distributed among the daughter cells, thereby maintaining the latent infection of the virus in the cell population. LANA can regulate the transcription of viral and host cell genes, and regulate certain host cell genes to promote cell survival. LANA can be used to study the viral DNA tethering structure .
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