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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
choline transporter
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "choline transporter" in MCE Product Catalog:
Target:
Research Areas:
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) . Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [ 3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively .
Cat. No.: HY-176710
Research Areas:
PAD-PF2 is a PAD family inhibitor, as well as a κ-opioid receptor agonist (EC50 = 7.55 μM) and an M1 muscarinic acetylcholine receptor antagonist (IC50 = 12.3 μM). The IC50 values of PAD-PF2 against PAD1, PAD2, PAD3 and PAD4 are 109 nM, 27.9 nM, 106 nM and 20.1 nM, respectively. PAD-PF2 binds to the common allosteric pocket of PAD1-4, and its inhibitory effects on PAD2 and PAD4 are Ca 2+-dependent. PAD-PF2 inhibits protein citrullination in neutrophils. PAD-PF2 is applicable to research related to rheumatoid arthritis, neurodegenerative diseases and cancer .
Cat. No.: HY-16934
CAS No.: 1649450-12-3
Target:
Research Areas:
ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki
values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively .
Cat. No.: HY-123858
CAS No.: 2002495-17-0
Target:
Research Areas:
VU6001221 is a blood-brain barrier permeable Choline Transporter (CHT) inhibitor (IC50 = 270 nM). VU6001221 increases the likelihood of extracellular choline elevation activating synaptic α7 nicotine ACh receptors. VU6001221 attenuates potassium-induced ACh levels in the prefrontal cortex .
Cat. No.: HY-P703351
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SLC5A7; Solute Carrier Family 5 (choline transporter), Member 7; Solute Carrier Family 5 Member 7; Motor Neuronopathy, Distal Hereditary, Type VIIA; CHT1; Hemicholinium-3-Sensitive choline transporter; High Affinity choline transporter 1; SLC5A7 Protein;
Cat. No.: HY-P703930
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SLC44A1; Solute Carrier Family 44 (choline transporter), Member 1; Prev. CDW92; choline transporter-Like Protein; CTL1; CD92 Antigen; CD92; CONATOC; choline transporter-Like Protein 1; CDw92; CHTL1; Solute Carrier Family 44 Member 1; CDW92 Antigen
Cat. No.: HY-P702042
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SLC44A1; Solute Carrier Family 44 (choline transporter), Member 1; Prev. CDW92; choline transporter-Like Protein; CTL1; CD92 Antigen; CD92; CONATOC; choline transporter-Like Protein 1; CDw92; CHTL1; Solute Carrier Family 44 Member 1; CDW92 Antigen
Species:
Source:
Cat. No.: HY-182290
Target:
Research Areas:
AChE/BChE-IN-36 is a dual acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with blood-brain barrier permeability. AChE/BChE-IN-36 mediates blood-brain barrier transport through specific interactions with choline transporters. AChE/BChE-IN-36 can be used for the research of Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
