312-45-8
Chemical Structure
Hemicholinium 3
Synonym(s): Hemicholinium dibromide
- CAS No.: 312-45-8
- Formula:C24H34Br2N2O4
- Molecular Weight:574.35
IUPAC Name: 2,2'-([1,1'-biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide
InChIKey: OPYKHUMNFAMIBL-UHFFFAOYSA-L
SMILES: C[N+]1(C)CC(C2=CC=C(C3=CC=C(C4(O)C[N+](C)(C)CCO4)C=C3)C=C2)(O)OCC1.[Br-].[Br-]
Biological Activity: Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh)[1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2].
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Hemicholinium 3 | 99.89% | Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh). Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively. | ||||||||||||||||||||
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Similarity Score 0.97
HY-114081AHemicholinium chloride -
Similarity Score 0.53
HY-178158SQS-IN-1 -
Similarity Score 0.48
HY-W0176704,4'-Bis(oxiran-2-ylmethyl)-1,1'-biphenyl -
Similarity Score 0.47
HY-W0139374,4'-Bibenzoic acid -
Similarity Score 0.47
HY-W0170634,4'-Diacetylbiphenyl -
Similarity Score 0.46
HY-128854Dimethyl biphenyl-4,4'-dicarboxylate -
Similarity Score 0.46
HY-121290BPH-651 -
Similarity Score 0.46
HY-W613379Biphenyl-4,4'-diacetic acid -
Similarity Score 0.46
![Ethyl 4'-hydroxy-[1,1'-biphenyl]-4-carboxylate Chemical Structure](//file.medchemexpress.com/product_pic/hy-w140616.gif)
HY-W140616Ethyl 4'-hydroxy-[1,1'-biphenyl]-4-carboxylate -
Explore the MedChemAI to find more analogs
![Ethyl 4'-hydroxy-[1,1'-biphenyl]-4-carboxylate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w140616.gif)
References
- [1]. PATRICE GUYENET, et al. Inhibition by Hemicholinium-3 of [14C] Acetylcholine Synthesis and [3H] Choline High-Affinity Uptake in Rat Striatal Synaptosomes.Molecular Pharmacology September 1973, 9 (5) 630-639.
- [2]. Péter Mandl, et al. Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons. Neurochem Int. 2006 Sep;49(4):327-33. [Content Brief]
