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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
collagen-IV
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "collagen-IV" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC50s of 4.67 nM and 7.39 nM, respectively. VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production .
Cat. No.: HY-P3369
CAS No.: 2417491-82-6
Synonyms: AXT-107
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Cat. No.: HY-174719
Target:
Research Areas:
Human ELANE mRNA encodes the human elastase (ELANE) protein, a member of serine proteases family. ELANE may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin.
Cat. No.: HY-174313
Research Areas:
Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research .
Cat. No.: HY-P72148
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: COL4A3; Goodpasture Antigen; collagen Type IV Alpha 3 Chain; ATS3A; collagen, Type IV, Alpha 3 (Goodpasture Antigen); ATS3B; collagen Alpha-3(IV) Chain; ATS2; Tumstatin; ATS3; collagen IV, Alpha-3 Polypeptide; BFH2; collagen IV Alpha 3 Chain
Cat. No.: HY-P75683
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: COL4A3; Goodpasture Antigen; collagen Type IV Alpha 3 Chain; ATS3A; collagen, Type IV, Alpha 3 (Goodpasture Antigen); ATS3B; collagen Alpha-3(IV) Chain; ATS2; Tumstatin; ATS3; collagen IV, Alpha-3 Polypeptide; BFH2; collagen IV Alpha 3 Chain
Cat. No.: HY-P81201
Synonyms: Arresten; Canstatin; COL4A1; HANAC; ICH; POREN1; collagen Alpha 1(IV) Chain; collagen IV Alpha 1 Polypeptide; collagen Of Basement Membrane Alpha 1 Chain; collagen Of Basement Membrane Alpha 2 Chain; collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; collagen alpha-1(IV) chain preproprotein; collagen alpha-1(IV) chain preproprotein; Col4a1 protein; collagen of basement membrane, alpha-1 chain; collagen IV, alpha-1 polypeptide; collagen alpha-1(IV) chain; COL4A1 NC1 domain; CO4A1_HUMAN; collagen Ⅳ; collagen Type Ⅳ.
Cat. No.: HY-181430
CAS No.: 798546-78-8
Target:
Research Areas:
PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR-mediated activation of latent TGF-β1. PXS 25 inhibits conversion of high glucose-induced latent TGF-β1 to active TGF-β1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin, collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy .
Cat. No.: HY-181431
CAS No.: 1253691-50-7
Target:
Research Areas:
PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 (HY-181430). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-β1. PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts. PXS 64 reduces TGFβ-mediated collagen IV, fibronectin, MCP-1, and phospho-smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring .
Cat. No.: HY-P86639
Synonyms: Arresten; BSVD; CO4A1_HUMAN; COL4A1; COL4A1 NC1 domain; COL4A2; COL4A3; COL4A4; COL4A5; collagen alpha-1; IV; chain; collagen IV Alpha 1 Polypeptide; collagen IV Alpha 2 Polypeptide; collagen Of Basement Membrane Alpha 1 Chain; collagen Of Basement Membrane Alpha 2 Chain; collagen Type IV Alpha 1; collagen type IV alpha 1 chain; collagen Type IV Alpha 2; collagen Type IV Alpha 3; collagen Type IV Alpha 4; collagen Type IV Alpha 5; RatOR
Cat. No.: HY-P71444
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: COL4A1; COL4A1 Protein; collagen Type IV Alpha 1 Chain; Arresten; collagen Alpha-1(IV) Chain; COL4A1s; collagen Of Basement Membrane, Alpha-1 Chain; PADMAL; collagen IV, Alpha-1 Polypeptide; BSVD1; collagen, Type IV, Alpha 1; RATOR; COL4A1 NC1 Domain; BSV
Cat. No.: HY-P704062
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: COL4A1; COL4A1 Protein; collagen Type IV Alpha 1 Chain; Arresten; collagen Alpha-1(IV) Chain; COL4A1s; collagen Of Basement Membrane, Alpha-1 Chain; PADMAL; collagen IV, Alpha-1 Polypeptide; BSVD1; collagen, Type IV, Alpha 1; RATOR; COL4A1 NC1 Domain; BSV
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
