PXS 25
PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR-mediated activation of latent TGF-β1. PXS 25 inhibits conversion of high glucose-induced latent TGF-β1 to active TGF-β1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin, collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy.
For research use only. We do not sell to patients.
- CAS No.: 798546-78-8
- Formula: C15H23O8P
- Molecular Weight:362.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PXS 25 (1-200 µM; 72 h) inhibits high glucose-induced activation of latent TGF-β1, downstream Smad2 signaling, and extracellular matrix production in normoxic HK-2 cells but does not affect hypoxia-related responses[1].
PXS 25 (1-1000 µM; 72 h) shows no cytotoxic effect on HK-2 cells in normoxic or hypoxic conditions with 5 mM or 30 mM D-glucose (HY-B0389)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HK-2 cells
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Concentration:1 μM, 10 μM, 100 μM, 200 μM, 1000 μM
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Incubation Time:72 h
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Result:Exhibited no cytotoxic effect on HK-2 cells cultured in 5 mM or 30 mM D-glucose under normoxic or hypoxic conditions at concentrations up to 1000 μM.
Chemical Information
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CAS No. 798546-78-8
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Molecular Weight 362.31
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Formula C15H23O8P
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SMILES
O=P(O)(O)CC[C@H]([C@H]([C@@H]([C@@H]1O)O)O)O[C@@H]1OC2=C(C=C(C=C2)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PXS 25 Related Classifications
HY-181430 Related Classifications
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- PXS 25
- 798546-78-8
- PXS25
- PXS-25
- TGF-beta/Smad
- Smad signaling
- extracellular matrix production
- phosphorylated Smad 2
- diabetic nephropathy
- CI-M6PR
- fibronectin
- cation-independent mannose 6-phosphate receptor
- M6P-containing proteins
- TGF-β?
- collagen IV
- D-glucose
- skin fibroblasts
- HK-2 cells
- hypoxic conditions
- proximal tubule cells
- normoxic conditions
- Inhibitor
- inhibitor
- inhibit