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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
femur
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "femur" in MCE Product Catalog:
1
1 Cited Publications
LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats .
Synonyms: Oligolevulose
Cat. No.: HY-P3497A
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Cat. No.: HY-176547
CAS No.: 3069945-78-1
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FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50s of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), respectively. FGFR2/3-IN-3 has effective activity against both wild-type and mutant FGFR3. FGFR2/3-IN-3 has low CYP3A4 inhibitory effect and hERG toxicity. FGFR2/3-IN-3 improves the imbalance between chondrocyte proliferation and differentiation and promotes bone growth by inhibiting the signaling pathway mediated by mutant FGFR3. FGFR2/3-IN-3 shows a growth-promoting effect in a dwarfism mouse model and has the potential to study bone development disorder-related diseases such as achondroplasia (ACH) .
Cat. No.: HY-P3497
CAS No.: 2407782-70-9
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Cat. No.: HY-W746269
CAS No.: 129794-24-7
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KCA 098 is an orally active benzofuroquinoline derivative. KCA 098 can inhibit bone resorption and stimulat bone formation of chick embryo. KCA 098 can increase calcium and phosphorus content as well as the amount of force required to break the femur from ovariectomized rats. KCA 098 can be used for the research of bone diseases .
Cat. No.: HY-138089
CAS No.: 122370-91-6
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17β-Hydroxy exemestane (17-H-EXE) is the primary active metabolite of Exemestane (HY-13632). 17β-Hydroxy exemestane is an aromatase inhibitor (IC50 = 69 nM) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). 17β-Hydroxy exemestane stimulates growth of AR- and ERα-positive MCF-7 (EC50= 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7 cells. 17β-Hydroxy exemestane inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae in ovariectomized rats .
Cat. No.: HY-185983
CAS No.: 3113145-84-6
Ale-a12K2 is a peptide-based ionizable lipid modified with bone-binding alendronate. Ale-a12K2 mediates targeted delivery of mRNA to bone tissues. Ale-a12K2 increases mRNA expression levels in the femur and tibia .
Cat. No.: HY-185982
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Ale-a12K4 is a peptide-derived ionizable lipid originating from a12K4. Ale-a12K4 mediates the targeted delivery of mRNA to bone tissues. Ale-a12K4 can be used for the preparation of lipid nanoparticles .
Cat. No.: HY-183407
CAS No.: 50648-52-7
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R 8231 is a reversible inhibitor of Alkaline Phosphatase. R 8231 potently inhibits alkaline phosphatases derived from human liver, bone, kidney and spleen, while exerts weak effects on those derived from human intestine and placenta. The IC50 value of R 8231 for inhibiting bone alkaline phosphatase from adult rabbits is approximately 1 μM, whereas that for inhibiting chicken bone alkaline phosphatase is approximately 100 μM. R 8231 can be used for alkaline phosphatase histochemistry, phosphatase activity identification and bone metabolism-related studies .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
