50648-52-7
Chemical Structure
R 8231
- CAS No.: 50648-52-7
- Formula:C13H11BrN2O4S
- Molecular Weight:371.21
InChIKey: RLCKOBLWSSOAOS-UHFFFAOYSA-N
SMILES: O=C(C(O)=O)O.BrC1=CC=CC(C2N=C3SC=CN3C2)=C1
Biological Activity:
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R 8231 | R 8231 is a reversible inhibitor of Alkaline Phosphatase. R 8231 potently inhibits alkaline phosphatases derived from human liver, bone, kidney and spleen, while exerts weak effects on those derived from human intestine and placenta. The IC50 value of R 8231 for inhibiting bone alkaline phosphatase from adult rabbits is approximately 1 μM, whereas that for inhibiting chicken bone alkaline phosphatase is approximately 100 μM. R 8231 can be used for alkaline phosphatase histochemistry, phosphatase activity identification and bone metabolism-related studies. |
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- [1]. Borgers M. The cytochemical application of new potent inhibitors of alkaline phosphatases. J Histochem Cytochem. 1973;21(9):812-824. [Content Brief]
- [2]. Van Belle H, et al. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clinical chemistry. 1976 Jul;22(7):972-6. [Content Brief]
- [3]. Reynolds JJ, et al. Comparison of the inhibition of avian and mammalian bone alkaline phosphatases by levamisole and compound R8231. Experientia. 1977;33(2):154-155. [Content Brief]
- [4]. Mörnstad H, et al. Calcium-stimulated ATPase activity in homogenates of the secretory enamel organ in the rat. Scandinavian journal of dental research. 1978 Jan;86(1):1-11. [Content Brief]
Keywords
