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Cat. No.: HY-185982

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Ale-a12K4

Ale-a12K4 is a peptide-derived ionizable lipid originating from a12K4. Ale-a12K4 mediates the targeted delivery of mRNA to bone tissues. Ale-a12K4 can be used for the preparation of lipid nanoparticles.

For research use only. We do not sell to patients.

Formula: C₆₈H₁₃₈N₆O₁₁P₂
Molecular Weight:1277.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ale-a12K4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Ale-a12K4 is conjugated with the bone-binding small molecule alendronic acid (HY-B0631) to serve as an inducer of bone-targeted mRNA expression; when formulated into lipid nanoparticles, it enhances mRNA expression in the femur and tibia and improves the specificity of mRNA expression within bone tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 1277.80
Formula C₆₈H₁₃₈N₆O₁₁P₂
SMILES

CCCCCCCCCCCCN(CCCC[C@H](NC(CCC(NCCCC(P(O)(O)=O)(O)P(O)(O)=O)=O)=O)C(N[C@H](C(N)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCCCCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin Y, et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nature materials. 2026 Jan;25(1):133-145. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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