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Isoforms Recommended:	Adenosine A_2A receptor (A_2AR)

Results for "

hA2AAR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (6) Androgen Receptor (1) Carbonic Anhydrase (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163701

hA2AAR antagonist 1	Adenosine Receptor	Cancer
hA2AAR antagonist 1 (compound 4a) is a highly selective *hA2AAR* antagonist with a K_i of 5 nM. hA2AAR antagonist 1 can be used in the study of immune-oncology .

HY-175487

A2AAR antagonist 4	Adenosine Receptor	Cancer
A2AAR antagonist 4 is an orally active A_2A Adenosine receptor antagonist with a K_i of 0.36 nM and a K_B of 1 nM at hA_2AAR. A2AAR antagonist 4 fully inhibits hA_2AAR and hA_2bAR at 10 μM. A2AAR antagonist 4 can be used for research of cancer, such as MC38 tiumor .

HY-146979

hA2A/hCA XII modulator 1	Adenosine Receptor Carbonic Anhydrase	Cancer
hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent **hA_2A adenosine receptor (hA_2AAR) antagonist with K_i*s of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR,* hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with K_is of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research .

HY-175851

A2AAR antagonist 5	Adenosine Receptor	Neurological Disease
A2AAR antagonist 5 is a selective *A_2AAR* antagonist. A2AAR antagonist 5 inhibits NECA-stimulated adenylyl cyclase activity in *hA_2AAR*-expressing CHO cells with an IC₅₀ value of 1863 nM. A2AAR antagonist 5 possesses strong free radical scavenging activity, with an EC₅₀ value of 22.21 μM in the DPPH assay. A2AAR antagonist 5 exerts notable neuroprotective effects in in vitro cerebral ischemia models. A2AAR antagonist 5 can be used for the study of cerebral ischemia .

HY-179605

AR ligand-49	Androgen Receptor	Others
AR ligand-49 (Compound 4q) is a dual ligand for the adenosine A_2A receptor (A_2AAR) and the A₃ receptor (A₃AR). Its K_i values are 15 and 4.5 nM respectively. AR ligand-49 exhibits reverse agonistic activity at *hA_2AAR* and antagonistic activity at hA₃AR. AR ligand-49 can be used for the study of the design and development of adenosine receptor ligands .

HY-179681

A2A/A3 agonist-1	Adenosine Receptor	Inflammation/Immunology
A2A/A3 agonist-1 is a dual A_2A/A₃ adenosine receptor agonist. A2A/A3 agonist-1 has a K_i value of 2.9 nM and an EC₅₀ of 0.51 nM for *hA_2AAR. A2A/A3* agonist-1 has a K_i of 0.8 nM and an EC₅₀ < 0.10 nM for hA₃AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases .

HY-182432

A3AR antagonist-7	Adenosine Receptor	Cancer
A3AR antagonist-7 is a conjugable human A3 adenosine receptor (A3AR) antagonist with a K_i value of 31.8 nM. A3AR antagonist-7 is applicable to the research of melanoma, breast cancer and colorectal cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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hA2AAR

Inhibitors & Agonists