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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
hTRPA1
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "hTRPA1" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-N1378
CAS No.: 19309-14-9
Synonyms: (E)-Cardamomin; (E)-Alpinetin chalcone
Category:
Neurological Disease Alpinia katsumadai Hayata Plants Flavonoids Chalcones Phenols Polyphenols Disease Research Fields Cancer Zingiberaceae
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1 Cited Publications
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BAY-390, a chemical probe, is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation [1].
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Other Monoterpenes Terpenoids Plants Ericaceae Disease Research Fields Inflammation/Immunology Rhododendron anthopogonoides Maxim. Cancer
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AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
Cat. No.: HY-N12605
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Cat. No.: HY-N1378R
CAS No.: 19309-14-9
Synonyms: (E)-Cardamomin (Standard); (E)-Alpinetin chalcone (Standard)
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Cat. No.: HY-136820S1
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Cat. No.: HY-183281
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TRPV3 antagonist-1 is a selective TRPV3 channel antagonist with an IC50 of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity [1].
Cat. No.: HY-108329R
CAS No.: 1883711-97-4
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AM-0902 (Standard) is the analytical standard of AM-0902 (HY-108329). This product is intended for research and analytical applications. AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
Cat. No.: HY-136820
CAS No.: 38668-01-8
Research Areas:
Taurultam is the major active hydrolytic metabolite of Taurolidine (HY-W011522), which selectively activates hTRPA1 to trigger effects in sensory neurons. Taurultam exhibits activity against SARS-CoV-2 variants, influenza A viruses (H1N1, H3N2) and influenza B viruses. Taurultam induces mild tracheal sensory nerve stimulation and CGRP release in mice. Taurultam can be used in studies related to SARS-CoV-2 infection, influenza virus infection, and co-infection with SARS-CoV-2 and influenza A virus. [1]
Cat. No.: HY-182517
CAS No.: 2225980-49-2
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AG1529 is a TRPV1 inhibitor and capsaicinoid-based soft agent with a human TRPV1 IC50 of 0.9-0.93 μM. AG1529 reversibly blocks capsaicin-evoked TRPV1 activation, binds to the TRPV1 capsaicin binding site, moderately affects pH-induced TRPV1 gating, and does not alter voltage- or heat-mediated TRPV1 responses. AG1529 suppresses TRPV1-mediated neuronal excitability, reduces capsaicin- and pH-evoked neuronal firing, abolishes histaminergic and inflammation-mediated TRPV1 sensitization. AG1529 exhibits anti-nociceptive and antipruritic effects, attenuates in vivo hyperalgesia and pruritus, dose-dependently reduces acute histaminergic itch in rodents, and mildly blocks hTRPA1 and hTRPM8 channel activity. AG1529 undergoes hydrolysis and dermal deactivation, minimizes TRPV1-associated side reactions, does not evoke capsaicin-like burning sensation, and does not disrupt physiological thermal regulation. AG1529 can be used for the research of inflammatory cutaneous nociception and acute histaminergic pruritus [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
