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hTRPA1

" in MedChemExpress (MCE) Product Catalog:

10

阻害剤およびアゴニスト

5

天然物

製品番号 製品名 Target 研究分野 構造式
  • HY-N1378
    (E)-Cardamonin
    4 Publications Verification

    (E)-Cardamomin; (E)-Alpinetin chalcone

    		 TRP Channel Apoptosis Neurological Disease Cancer
    (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
    (E)-Cardamonin
  • HY-N7117
    1,4-Cineole

    		Environmental Pollutants TRP Channel Neurological Disease
    1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca 2+ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression [1] .
    1,4-Cineole
  • HY-108329
    AM-0902

    		TRP Channel Neurological Disease Inflammation/Immunology
    AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
    AM-0902
  • HY-148236
    BAY-390
    1 Publications Verification

    		 TRP Channel Inflammation/Immunology
    BAY-390, a chemical probe, is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation [1].
    BAY-390
  • HY-N12605
    hTRPA1-IN-1

    		TRP Channel Neurological Disease
    hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC50 of 2 μM [1].
    hTRPA1-IN-1
  • HY-N1378R
    (E)-Cardamonin (Standard)

    (E)-Cardamomin (Standard); (E)-Alpinetin chalcone (Standard)

    		 Reference Standards TRP Channel Apoptosis Neurological Disease Cancer
    (E)-Cardamonin (Standard) is the analytical standard of (E)-Cardamonin. This product is intended for research and analytical applications. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
    (E)-Cardamonin (Standard)
  • HY-N7117R
    1,4-Cineole (Standard)

    		Reference Standards TRP Channel Neurological Disease
    1,4-Cineole (Standard) is the analytical standard of 1,4-Cineole (HY-N7117). 1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca 2+ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression [1] .
    1,4-Cineole (Standard)
  • HY-183281
    TRPV3 antagonist-1

    		TRP Channel Others
    TRPV3 antagonist-1 is a selective TRPV3 channel antagonist with an IC50 of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity [1].
    TRPV3 antagonist-1
  • HY-108329R
    AM-0902 (Standard)

    		Reference Standards TRP Channel Neurological Disease Inflammation/Immunology
    AM-0902 (Standard) is the analytical standard of AM-0902 (HY-108329). This product is intended for research and analytical applications. AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
    AM-0902 (Standard)
  • HY-182517
    AG1529

    		TRP Channel Inflammation/Immunology
    AG1529 is a TRPV1 inhibitor and capsaicinoid-based soft agent with a human TRPV1 IC50 of 0.9-0.93 μM. AG1529 reversibly blocks capsaicin-evoked TRPV1 activation, binds to the TRPV1 capsaicin binding site, moderately affects pH-induced TRPV1 gating, and does not alter voltage- or heat-mediated TRPV1 responses. AG1529 suppresses TRPV1-mediated neuronal excitability, reduces capsaicin- and pH-evoked neuronal firing, abolishes histaminergic and inflammation-mediated TRPV1 sensitization. AG1529 exhibits anti-nociceptive and antipruritic effects, attenuates in vivo hyperalgesia and pruritus, dose-dependently reduces acute histaminergic itch in rodents, and mildly blocks hTRPA1 and hTRPM8 channel activity. AG1529 undergoes hydrolysis and dermal deactivation, minimizes TRPV1-associated side reactions, does not evoke capsaicin-like burning sensation, and does not disrupt physiological thermal regulation. AG1529 can be used for the research of inflammatory cutaneous nociception and acute histaminergic pruritus [1] .
    AG1529

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