38668-01-8
Chemical Structure
Taurultam
- CAS 番号: 38668-01-8
- Formula:C3H8N2O2S
- Molecular Weight:136.17
IUPAC Name: 1,2,4-thiadiazinane 1,1-dioxide
InChIKey: RJGYJMFQWGPBGM-UHFFFAOYSA-N
SMILES: O=S1(NCNCC1)=O
Biological Activity: Taurultam is the major active hydrolytic metabolite of Taurolidine (HY-W011522), which selectively activates hTRPA1 to trigger effects in sensory neurons. Taurultam exhibits activity against SARS-CoV-2 variants, influenza A viruses (H1N1, H3N2) and influenza B viruses. Taurultam induces mild tracheal sensory nerve stimulation and CGRP release in mice. Taurultam can be used in studies related to SARS-CoV-2 infection, influenza virus infection, and co-infection with SARS-CoV-2 and influenza A virus.[1][2]
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Taurultam | Taurultam is the major active hydrolytic metabolite of Taurolidine (HY-W011522), which selectively activates hTRPA1 to trigger effects in sensory neurons. Taurultam exhibits activity against SARS-CoV-2 variants, influenza A viruses (H1N1, H3N2) and influenza B viruses. Taurultam induces mild tracheal sensory nerve stimulation and CGRP release in mice. Taurultam can be used in studies related to SARS-CoV-2 infection, influenza virus infection, and co-infection with SARS-CoV-2 and influenza A virus. | |||||||||||||||||||||
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Taurultam-d2 hydrochloride | Taurultam-d2 hydrochloride is the d2-labeled Taurultam (HY-136820) hydrochloride. Taurultam is the major active hydrolytic metabolite of Taurolidine (HY-W011522), which selectively activates hTRPA1 to trigger effects in sensory neurons. Taurultam exhibits activity against SARS-CoV-2 variants, influenza A viruses (H1N1, H3N2) and influenza B viruses. Taurultam induces mild tracheal sensory nerve stimulation and CGRP release in mice. Taurultam can be used in studies related to SARS-CoV-2 infection, influenza virus infection, and co-infection with SARS-CoV-2 and influenza A virus. | |||||||||||||||||||||
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- [1]. Luo R, et al. Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus. BMC microbiology. 2025 May 15;25(1):292. [Content Brief]
- [2]. Kichko TI, et al. Taurolidine and congeners activate hTRPA1 but not hTRPV1 channels and stimulate CGRP release from mouse tracheal sensory nerves. Pharmacology research & perspectives. 2016 Feb;4(1):e00204. [Content Brief]
Keywords
