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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
iBMDMs
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "iBMDMs" in MCE Product Catalog:
261
261 Publications Verification
Art. -Nr.: HY-P0175
CAS. Nr.: 1236188-16-1
Synonyms: 740YPDGFR; PDGFR 740Y-P
1
1 Cited Publications
Art. -Nr.: HY-N9447
CAS. Nr.: 79595-97-4
Category:
Art. -Nr.: HY-18711A
CAS. Nr.: 1174161-86-4
Synonyms: Metatinib anhydrous; c-Met inhibitor 2
Target:
Forschungsgebiete:
SCR-1481B1 (Metatinib anhydrous; c-Met inhibitor 2) is an inhibitor of the N-terminal fragment of Gasdermin D (GSDMD), with an IC50 of 1.04 μM and a Ka of 0.42 μM in mice. SCR-1481B1 effectively blocks GSDMD-NT oligomerization and pore formation, inhibits GSDMD-mediated pyroptosis (Pyroptosis), preserves mitochondrial integrity, and reduces proinflammatory cytokine secretion. SCR-1481B1 also inhibits angiogenesis, exerts GSDMD-independent antitumor effects, and enhances the infiltration of antitumor immune cells. SCR-1481B1 is also an inhibitor targeting to c-MET and VEGFR2, can be used in studies related to melanoma and sepsis .
Art. -Nr.: HY-P0175A
Synonyms: 740YPDGFR TFA; PDGFR 740Y-P TFA
Art. -Nr.: HY-178049A
Target:
Forschungsgebiete:
UM-259 hydrochloride is a STING inhibitor with activity against both murine and human STING (including the STING R232 mutant). UM-259 hydrochloride inhibits STING-dependent signaling pathways, blocks STING oligomerization, and acts on human primary CD14 + monocytes. UM-259 hydrochloride can be used for research on amyotrophic lateral sclerosis, lupus erythematosus, Aicardi-Goutières syndrome, and infant-onset STING-associated vasculopathy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
