37 Results for "

itraconazole

" in MedChemExpress (MCE) Product Catalog:
Products (37)

37 Results for "itraconazole" in MCE Product Catalog:

24
24 Cited Publications
Cat. No.: HY-17514
CAS No.: 84625-61-6
Synonyms: R51211
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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Cat. No.: HY-12772
CAS No.: 112559-91-8
Purity:  99.80%
Synonyms: R-63373
Target:  

Fungal Drug Metabolite

Research Areas:  

Others

Hydroxy Itraconazole (R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
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Cat. No.: HY-12772S
CAS No.: 2070015-20-0
Purity:  99.71%
Synonyms: R-63373-d8
Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
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Cat. No.: HY-17514S
CAS No.: 1217510-38-7
Synonyms: R51211-d5
Itraconazole-d5 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .
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Cat. No.: HY-17514S1
CAS No.: 1217512-35-0
Synonyms: R51211-d3
Itraconazole-d3 (R51211-d3) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
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Cat. No.: HY-17514R
CAS No.: 84625-61-6
Synonyms: R51211 (Standard)
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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Cat. No.: HY-117789
CAS No.: 112560-33-5
Synonyms: keto-ITZ
Target:  

Cytochrome P450

Research Areas:  

Infection Cancer

Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam .
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Cat. No.: HY-17514S2
CAS No.: 1309272-50-1
Synonyms: R51211-d9
Itraconazole-d9 is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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Cat. No.: HY-N13388
CAS No.: 27939-38-4
Synonyms: UGT1A6
5-Hydroxytryptophol-O-glucuronide (UGT1A6) is an authentic glucuronide standard and probe metabolite. 5-Hydroxytryptophol-O-glucuronide is used to detect the activity of human UGT1A6 in in vitro systems including human liver microsomes and recombinant UGT1A6 .
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Cat. No.: HY-117485
CAS No.: 1776931-05-5
Target:  

Hedgehog

Research Areas:  

Inflammation/Immunology

CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis .
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Cat. No.: HY-12772A
CAS No.: 207970-87-4
Synonyms: rel-R-63373
Target:  

Drug Isomer

Research Areas:  

Infection

rel-Hydroxy Itraconazole (rel-R-63373) is a relative stereoisomer of Hydroxy Itraconazole. Hydroxy Itraconazole is the major active metabolite of the antifungal compound Itraconazole (HY-17514) .
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Cat. No.: HY-12772S3
Synonyms: R-63373-d6
Hydroxy Itraconazole-d6 (R-63373-d6) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
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Cat. No.: HY-12772S4
Synonyms: (2S)-R-63373-d8
(2S)-Hydroxy Itraconazole-d8 ((2S)-R-63373-d8) is the enantiomer of Hydroxy Itraconazole-d8 (R-63373-d8) (HY-12772S). Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
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Cat. No.: HY-12772S1
CAS No.: 1217516-26-1
Synonyms: (2R,4S)-R-63373-d8
(2R,4S)-Hydroxy Itraconazole-d8 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].
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Cat. No.: HY-12772S2
CAS No.: 1217524-77-0
Purity:  99.40%
Synonyms: (2R,4S)-R-63373-d5
(2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole .
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Cat. No.: HY-12772R
CAS No.: 112559-91-8
Synonyms: itraconazole metabolite Hydroxy itraconazole (Standard); R-63373 (Standard)
Research Areas:  

Others

Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .
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Cat. No.: HY-159150
CAS No.: 2762922-66-5
Target:  

HIV

Research Areas:  

Infection

HIV-1 inhibitor-71 (compound 2a) blocks the transport of endocytosed HIV-1 particles into nuclear envelope invagination (NEIs) that can inhibit productive infection .
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Cat. No.: HY-Z8939
CAS No.: 89848-49-7
Synonyms: Isopropyl itraconazole
Target:  

Drug Intermediate

Research Areas:  

Others

Itraconazole impurity 9 (Isopropyl Itraconazole) is an impurity of Itraconazole.
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Cat. No.: HY-Z8940
CAS No.: 252964-65-1
Synonyms: trans-itraconazole
Target:  

Drug Intermediate

Research Areas:  

Others

Itraconazole impurity 10 (trans-Itraconazole) is an impurity of Itraconazole.
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Cat. No.: HY-Z8941
CAS No.: 89848-51-1
Synonyms: Butyl itraconazole
Target:  

Drug Intermediate

Research Areas:  

Others

Itraconazole impurity 11 (Butyl Itraconazole) is an impurity of Itraconazole.
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