1776931-05-5
Chemical Structure
CBR-096-4
- CAS No.: 1776931-05-5
- Formula:C35H40N8O4
- Molecular Weight:636.74
IUPAC Name: 4-(4-(4-(4-(((2R,4S)-2-((2H-1,2,3-triazol-2-yl)methyl)-2-phenyl-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
InChIKey: HCWHZLPXKGIFOM-UILZOBJNSA-N
SMILES: O=C1N(C(C)CC)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5O[C@](C6=CC=CC=C6)(CN7N=CC=N7)OC5)C=C4)CC3)C=C2
Biological Activity: CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis[1].
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CBR-096-4 | CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis. | |||||||||||||||||||||
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Keywords
