1217512-35-0
1217512-35-0
Chemical Structure
Itraconazole-d3
Synonym(s): R51211-d3
- CAS 番号: 1217512-35-0
- Formula:C35H35D3Cl2N8O4
- Molecular Weight:708.65
IUPAC Name: (R)-4-(1-hydroxy-2-((methyl-d3)amino)ethyl)benzene-1,2-diol
InChIKey: VHVPQPYKVGDNFY-NZHIZTFASA-N
SMILES: O=C(N(N=C1)C(C([2H])([2H])[2H])CC)N1C(C=C2)=CC=C2N(CC3)CCN3C(C=C4)=CC=C4OC[C@@H](CO5)O[C@]5(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7
Biological Activity: Itraconazole-d3 (R51211-d3) is the deuterium labeled Itraconazole (HY-17514)[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Itraconazole-d3 | 99.62% | Itraconazole-d3 (R51211-d3) is the deuterium labeled Itraconazole (HY-17514). Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. | ||||||||||||||||||||
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Itraconazole (Standard) | ≥98% | Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. | ||||||||||||||||||||
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Itraconazole-d5 | 99.55% | Itraconazole-d5 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. | ||||||||||||||||||||
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Itraconazole-d9 | 97.86% | Itraconazole-d9 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. | ||||||||||||||||||||
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Itraconazole solution | Itraconazole solution (R51211 solution) is mainly composed of Itraconazole (HY-17514). Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. | |||||||||||||||||||||
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Itraconazole | 99.59% | Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-Z8940Itraconazole impurity 10 -
Similarity Score 0.94
HY-Z8939Itraconazole impurity 9 -
Similarity Score 0.92
HY-12772Arel-Hydroxy Itraconazole -
Similarity Score 0.92
HY-12772RHydroxy Itraconazole (Standard) -
Similarity Score 0.92
HY-117789Keto-itraconazole -
Similarity Score 0.91
HY-Z8938Itraconazole impurity 8 -
Similarity Score 0.90
HY-Z8941Itraconazole impurity 11 -
Similarity Score 0.89
HY-Z8937Itraconazole impurity 7 -
Similarity Score 0.87
HY-12772(2S,4R)-Hydroxy Itraconazole -
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