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labile copper pools

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fluorescent Dye (5)
By Research Areas:	Metabolic Disease (2)

Inhibitors & Agonists

Fluorescent Dyes

Targets Recommended: VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W753658

Coppersensor-3	Fluorescent Dye	Others
Coppersensor-3 (CS3) is a bright small-molecule fluorescent probe for selective Cu(I) detection. Coppersensor-3 is selective and sensitive enough to image labile copper pools in living cells at endogenous, basal levels. Coppersensor-3 can be used for the cell biology of copper research .

HY-D3282

CCF1	Fluorescent Dye	Metabolic Disease
CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu ⁺ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a ^-/ ^- fibroblast cell models. CCF1 can be used for the research of Menkes disease .

HY-D3241

CD649.2	Fluorescent Dye	Others
CD649.2 is a red-emitting copper-targeted acylimidazole-reactive Fluorescent probe and a highly specific Cu ²⁺ detection reagent. CD649.2 enables visualization of labile Cu ²⁺ pools and their dynamic changes in living cells .

HY-D3284

CSF1	Fluorescent Dye	Others
CSF1 is a silicon-rhodamine-based, fluorescence-activatable probe with selectivity for Cu ⁺. CSF1 colocalizes with the endoplasmic reticulum in live cells .

HY-W783351

CS790AM coppersensor 790 acetoxymethyl ester	Fluorescent Dye	Metabolic Disease
CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu ⁺-targeted near-infrared fluorescent probe (λ_abs=760 nm, λ_em=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu ⁺ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b ^-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders .

Cat. No.	Product Name	Type

HY-D3282

CCF1	Fluorescent Dyes
CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu ⁺ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a ^-/ ^- fibroblast cell models. CCF1 can be used for the research of Menkes disease .

CCF1

Fluorescent Dyes

CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu ⁺ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a ^-/ ^- fibroblast cell models. CCF1 can be used for the research of Menkes disease .

HY-D3241

CD649.2	Fluorescent Dyes
CD649.2 is a red-emitting copper-targeted acylimidazole-reactive Fluorescent probe and a highly specific Cu ²⁺ detection reagent. CD649.2 enables visualization of labile Cu ²⁺ pools and their dynamic changes in living cells .

HY-D3284

CSF1	Fluorescent Dyes
CSF1 is a silicon-rhodamine-based, fluorescence-activatable probe with selectivity for Cu ⁺. CSF1 colocalizes with the endoplasmic reticulum in live cells .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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