1416808-87-1
Chemical Structure
CS790AM
Synonym(s): Coppersensor 790 acetoxymethyl ester
- CAS No.: 1416808-87-1
- Formula:C56H70BrN3O9S3
- Molecular Weight:1105.27
InChIKey: KICKDUODXWONIO-UHFFFAOYSA-M
SMILES: O=C(CC[N+]1=C(C(C)(C2=CC=CC=C21)C)/C=C/C(CCC/C3=C\C=C4N(C5=CC=CC=C5C\4(C)C)CCC(OCOC(C)=O)=O)=C3OC6=CC(SCCCSC)=C(C=C6)NCCCSC)OCOC(C)=O.[Br-]
Biological Activity: CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu+-targeted near-infrared fluorescent probe (λabs=760 nm, λem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu+ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders[1][2][3].
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CS790AM | CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu+-targeted near-infrared fluorescent probe (λabs=760 nm, λem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu+ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders. | |||||||||||||||||||||
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- [1]. Ackerman C M, et al. Analytical methods for imaging metals in biology: from transition metal metabolism to transition metal signaling[J]. Analytical chemistry, 2017, 89(1): 22-41.
- [2]. Hirayama T, et al. Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model. Proc Natl Acad Sci U S A. 2012;109(7):2228-2233. [Content Brief]
- [3]. Cotruvo JA Jr, et al. Synthetic fluorescent probes for studying copper in biological systems. Chem Soc Rev. 2015;44(13):4400-4414. [Content Brief]
Keywords
