8 Results for "

lncRNA

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "lncRNA" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N2585
CAS No.: 38927-54-7
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .
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1
1 Cited Publications
Cat. No.: HY-P72785
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4); Prev. CDKN2; Multiple Tumor Suppressor 1; Prev. MLM; CDKN2A/ARF Intron 2 lncRNA; P14ARF; Alternative Reading Frame; CDK4I; Inhibitor Of Cdk4 A; MTS1; MTS-1; P16; Truncated Tumor
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Cat. No.: HY-P10414A
Synonyms: KP1 (human) hydrochloride
Target:  

TGF-β Receptor

Research Areas:  

Infection Endocrinology

Klotho-derived peptide 1 hydrochloride (KP1 (human) hydrochloride) is a polypeptide with multiple activities including senescence inhibition and renal protection. Klotho-derived peptide 1 hydrochloride binds to TβR2 and ATAD3A, with a Kd value of 1.41 μM for binding to human TβR2 and a Kd value of 0.319 μM for binding to ATAD3A. By binding to TβR2, Klotho-derived peptide 1 hydrochloride blocks the TGF-β/Smad3 and downstream TGF-β signaling pathways, inhibits the expression of miR-223-3p, induces the expression of lncRNA-TUG1, restores endogenous Klotho at the post-transcriptional level, inhibits cellular senescence markers, fibroblast activation and renal tubular epithelial cell apoptosis, blocks cytochrome c release and caspase activation, maintains the integrity of mitochondrial ultrastructure, and restores mitochondrial protein levels. Klotho-derived peptide 1 hydrochloride enters renal tubular epithelial cells via endocytosis, protects against nephrotoxic and hypoxic injuries, and recapitulates the renal protective and anti-fibrotic effects of full-length Klotho. Klotho-derived peptide 1 hydrochloride can be used in research related to kidney diseases such as chronic kidney disease and SARS-CoV-2-associated acute kidney injury .
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Cat. No.: HY-P10414
Synonyms: KP1 (human)
Target:  

TGF-β Receptor

Research Areas:  

Infection Endocrinology

Klotho-derived peptide 1 (KP1 (human)) is a polypeptide with multiple activities including senescence inhibition and renal protection. Klotho-derived peptide 1 binds to TβR2 and ATAD3A, with a Kd value of 1.41 μM for binding to human TβR2 and a Kd value of 0.319 μM for binding to ATAD3A. By binding to TβR2, Klotho-derived peptide 1 blocks the TGF-β/Smad3 and downstream TGF-β signaling pathways, inhibits the expression of miR-223-3p, induces the expression of lncRNA-TUG1, restores endogenous Klotho at the post-transcriptional level, inhibits cellular senescence markers, fibroblast activation and renal tubular epithelial cell apoptosis, blocks cytochrome c release and caspase activation, maintains the integrity of mitochondrial ultrastructure, and restores mitochondrial protein levels. Klotho-derived peptide 1 enters renal tubular epithelial cells via endocytosis, protects against nephrotoxic and hypoxic injuries, and recapitulates the renal protective and anti-fibrotic effects of full-length Klotho. Klotho-derived peptide 1 can be used in research related to kidney diseases such as chronic kidney disease and SARS-CoV-2-associated acute kidney injury .
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Cat. No.: HY-P74538
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SOD2; Manganese-Containing Superoxide Dismutase; Superoxide Dismutase 2; Gastric Cancer–Associated lncRNA 1; Superoxide Dismutase [Mn], Mitochondrial; Gastric Cancer-Associated lncRNA 1; lncRNA-GC1; Mangano-Superoxide Dismutase; GClnc1; Mn Superoxide Dism
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Cat. No.: HY-P71073
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SOD2; Manganese-Containing Superoxide Dismutase; Superoxide Dismutase 2; Gastric Cancer–Associated lncRNA 1; Superoxide Dismutase [Mn], Mitochondrial; Gastric Cancer-Associated lncRNA 1; lncRNA-GC1; Mangano-Superoxide Dismutase; GClnc1; Mn Superoxide Dism
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Cat. No.: HY-105031
CAS No.: 99803-72-2
Research Areas:  

Cancer

Nerbacadol is significantly positively correlated with high expression of HOXB-AS4 and drug resistance in head and neck squamous cell carcinoma. Nerbacadol can be used in relevant research on head and neck squamous cell carcinoma .
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Cat. No.: HY-P78757
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PLXNB2; Ferroptosis-Associated lncRNA; Plexin B2; Plexin-B2; MM1; PLXNB2 Protein; KIAA0315; DJ402G11.3; PLEXB2; Nbla00445; LncFAL
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