3 Results for "

negative chronotropic agent

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "negative chronotropic agent" in MCE Product Catalog:

Phytolaccagenin
Phytolaccagenin
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Cat. No.: HY-N1433
CAS No.: 1802-12-6
Category:  

Triterpenes Terpenoids Phytolacca acinosa Roxb. Plants Disease Research Fields Inflammation/Immunology Phytolaccaceae

Target:  

Fungal mAChR Adrenergic Receptor Calcium Channel

Phytolaccagenin is a triterpenoid saponin aglycone, Antifungal agent, vasodilator, antihypertensive agent, and anti-inflammatory agent. Phytolaccagenin activates vascular and cardiac Muscarinic receptors, blocks cardiac β-adrenergic receptors, and inhibits voltage-dependent calcium channels in blood vessels. Phytolaccagenin inhibits the growth of Candida albicans and Cryptococcus neoformans. Phytolaccagenin induces vasodilation, produces negative inotropic and negative chronotropic effects, reduces mean arterial pressure, and inhibits LPS-induced inflammation. Phytolaccagenin exhibits enhanced antihypertensive effects in high salt-induced hypertensive rats. Phytolaccagenin can be used in the research of candidiasis, cryptococcosis, hypertension, and inflammation-related diseases .
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Tabernanthine
Tabernanthine
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Cat. No.: HY-N8421
CAS No.: 83-94-3
Category:  

Apocynaceae Alkaloids Plants Indole Alkaloids Tabernanthe iboga Baill.

Target:  

Potassium Channel

Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences .
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AWD 122-60
AWD 122-60
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Cat. No.: HY-165486
CAS No.: 108610-89-5
Target:  

Potassium Channel Calcium Channel

Research Areas:  

Cardiovascular Disease

AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias .
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