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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
non-sedating
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "non-sedating" in MCE Product Catalog:
Cat. No.: HY-19505
CAS No.: 425377-76-0
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TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties .
Synonyms: MRK-409
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MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic .
Cat. No.: HY-119832B
Purity: 99.72%
Synonyms: (S)-EGIS-2062 free acid; (S)-EGYT-2062 free acid
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(S)-Setastine ((S)-EGIS-2062 free acid) is a non-sedating, highly potent antagonist of H1 receptor-mediated responses. (S)-Setastine has a long-lasting antihistamine effect and good oral efficacy. (S)-Setastine can be used in the research of allergic diseases .
Cat. No.: HY-B0539S3
CAS No.: 1020719-34-9
Synonyms: Sch34117-d5
Cat. No.: HY-101869R
CAS No.: 233275-76-8
Synonyms: MRK-409 (Standard)
Target:
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MK-0343 (Standard) is the analytical standard of MK-0343. This product is intended for research and analytical applications. MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic .
Cat. No.: HY-123525
CAS No.: 550310-04-8
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COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration .
Cat. No.: HY-118910
CAS No.: 119810-68-3
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AHR-14310C is a potent, long-acting, nonsedating H1-antihistamine that prevents antigen-induced mucus formation in sensitive rats .
Cat. No.: HY-B0539S1
CAS No.: 1795024-82-6
Synonyms: Sch34117-d9
Cat. No.: HY-B0539S
CAS No.: 381727-29-3
Synonyms: Sch34117-d4
Cat. No.: HY-B0539R
CAS No.: 100643-71-8
Synonyms: Sch34117 (Standard)
Cat. No.: HY-B0539S4
Synonyms: Sch34117-d4 hydrobromide
Cat. No.: HY-B0539S2
CAS No.: 2713301-38-1
Cat. No.: HY-14939A
CAS No.: 279253-83-7
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Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a Ki of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED50 is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED50 is 0.51-1.4 mg/kg) in rats .
Cat. No.: HY-W665882
CAS No.: 34580-20-6
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Norketotifen is the active metabolite of Ketotifen (HY-B0157). Norketotifen exhibits skin anti-inflammatory activity, anti-malarial activity, and antipruritic activity against non-histamine-mediated dog itching in mice. Norketotifen effectively inhibits TNF-α release without causing any sedative side effects. Norketotifen can be used for research on non-sedating anti-inflammatory agents .
Cat. No.: HY-182548
CAS No.: 165383-52-8
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BTS 72664 is a broad-spectrum, non-sedating, orally effective anticonvulsant. Its anticonvulsant effect mainly arises from enhancing GABAA receptor (GABAA receptor)-mediated chloride channel currents, while it exerts weak blocking effects on Na + channels (Ki = 350 μM) and NMDA receptors (NMDA receptor) (IC50 = 43 μM). BTS 72664 prevents the elevation of extracellular glutamate, glycine and serine concentrations in neurons, reduces cerebral infarct size, promotes functional recovery, prevents multiple types of epileptic seizures, and has low sedative potential. BTS 72664 can be used for the research of epilepsy, stroke and migraine .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
