425377-76-0
425377-76-0
Chemical Structure
TPA-023B
- CAS No.: 425377-76-0
- Formula:C21H15F2N5O
- Molecular Weight:391.37
IUPAC Name: 2',6-difluoro-5'-(3-(2-hydroxypropan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl)-[1,1'-biphenyl]-2-carbonitrile
InChIKey: PCZLQMGFNUNVOM-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(F)=C1C2=CC(C3=CN=C4N3N=CC(C(C)(O)C)=N4)=CC=C2F
Biological Activity: TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TPA-023B | 98.45% | TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.59
HY-123840MRK-623 -
Similarity Score 0.58
HY-153584MRK-898 -
Similarity Score 0.57
HY-103512TP003 -
Similarity Score 0.49
HY-144091HPK1-IN-24 -
Similarity Score 0.47
HY-129393Etrumadenant -
Similarity Score 0.47
HY-11048NS11394 -
Similarity Score 0.47
HY-12953R-268712 -
Similarity Score 0.46
HY-149916A2AR-antagonist-1 -
Similarity Score 0.46
HY-125020NCGC00135472 -
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