425377-76-0
425377-76-0
Chemical Structure
TPA-023B
- CAS No.: 425377-76-0
- Formula:C21H15F2N5O
- Molecular Weight:391.37
IUPAC Name: 2',6-difluoro-5'-(3-(2-hydroxypropan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl)-[1,1'-biphenyl]-2-carbonitrile
InChIKey: PCZLQMGFNUNVOM-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(F)=C1C2=CC(C3=CN=C4N3N=CC(C(C)(O)C)=N4)=CC=C2F
Biological Activity: TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties[1].
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TPA-023B | 98.45% | TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties. | ||||||||||||||||||||
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