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Cat. No.: HY-14939A

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Vapitadine hydrochloride

Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a K_i of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED₅₀ is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED₅₀ is 0.51-1.4 mg/kg) in rats.

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CAS No.: 279253-83-7
Formule: C₁₇H₂₂Cl₂N₄O
Masse moléculaire:369.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Vapitadine hydrochloride Chemical Structure

CAS No.: 279253-83-7

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

Human H₁ Receptor

19 nM (Ki)

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Chemical Information

CAS No. 279253-83-7
Masse moléculaire 369.29
Formule C₁₇H₂₂Cl₂N₄O
SMILES

O=C(C1=CN=C2N1CCC3=CC=CC=C3C24CCNCC4)N.Cl.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Janssens F, et al., Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines. J Med Chem. 2005 Mar 24;48(6):2154-66. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
Pureté et documentation
Références

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Vapitadine hydrochloride

Voir tous les produits spécifiques à Isoform Histamine Receptor