550310-04-8
Chemical Structure
COR628
- CAS No.: 550310-04-8
- Formula:C16H23NO3S
- Molecular Weight:309.42
IUPAC Name: methyl 2-(cyclohexanecarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate
InChIKey: CXXTWRDDIQIUKA-UHFFFAOYSA-N
SMILES: O=C(OC)C1=C(SC(C)=C1CC)NC(C2CCCCC2)=O
Biological Activity: COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration[1].
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COR628 | COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration. | |||||||||||||||||||||
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