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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
nucleoporin
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "nucleoporin" in MCE Product Catalog:
5
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
Cat. No.: HY-170430
CAS No.: 3055558-98-7
Target:
Domaines de recherche:
HGC652 is a molecular glue degrader targeting TRIM21 with a TRIM21-dependent nuclear membrane disruption effect. HGC652 binds to the PRY-SPRY domain of TRIM21 with high affinity (Ka=0.061 μM), mediates the interaction between TRIM21 and NUP98, and redirects E3 ligase activity. By triggering the polyubiquitination and proteasomal degradation of nucleoporins (such as NUP155 and GLE1), HGC652 disrupts nuclear membrane integrity, alters nuclear morphology, induces genomic instability, and thereby induces cancer cell death .
Cat. No.: HY-169325
Target:
Domaines de recherche:
(S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98 .
Cat. No.: HY-W010514
CAS No.: 1460-57-7
Target:
Cat. No.: HY-W1125585
Target:
Domaines de recherche:
PRLX-93936 analog 1 is a TRIM21-targeting cytotoxin. PRLX-93936 analog 1 binds to the TRIM21 PRYSPRY domain, inducing TRIM21-mediated ubiquitination and degradation of nucleoporin proteins. PRLX-93936 analog 1 impairs nuclear trafficking, triggering cell death. PRLX-93936 analog 1 exhibits TRIM21-dependent cytotoxicity, suppressible by TRIM21 ligand HGC1g. PRLX-93936 analog 1 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P705107
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NUP85; FLJ12549; nucleoporin 85; FROUNT; NUP75; 85 KDa nucleoporin; Nuclear Pore Complex Protein Nup85; Pericentrin-1; nucleoporin 85kDa; NPHS17; nucleoporin Nup75; PCNT1; nucleoporin Nup85
Cat. No.: HY-P81292
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98 Nup96; nucleoporin 98kD; nucleoporin 98kDa; nucleoporin Nup96; nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P81292A
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98 Nup96; nucleoporin 98kD; nucleoporin 98kDa; nucleoporin Nup96; nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P85549
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98 Nup96; nucleoporin 98kD; nucleoporin 98kDa; nucleoporin Nup96; nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P703291
Pureté: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NUP50; nucleoporin Nup50; Prev. NPAP60L; Nuclear Pore-Associated Protein 60L; Nuclear Pore Complex Protein Nup50; nucleoporin 50kD; 50 KDa nucleoporin; NPAP60; nucleoporin 50kDa; nucleoporin 50; Nuclear Pore-Associated Protein 60 KDa-Like
Cat. No.: HY-P81292AA
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98 Nup96; nucleoporin 98kD; nucleoporin 98kDa; nucleoporin Nup96; nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P703236
Pureté: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NUP214; nucleoporin Nup214; nucleoporin 214; D9S46E; Nuclear Pore Complex Protein Nup214; N214; CAIN; CDNA, FLJ79316, Highly Similar To Nuclear Pore Complex Protein Nup214; CAN; nucleoporin 214kD (CAIN); CAN Protein, Putative Oncogene; Protein CAN; 214 KD
Cat. No.: HY-P72263
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NUP210; Nuclear Pore Membrane Glycoprotein 210; nucleoporin 210; Pore Membrane Protein Of 210 KDa; POM210; Nuclear Pore Protein Gp210; KIAA0906; nucleoporin 210kDa; GP210; nucleoporin Nup210; Nuclear Envelope Pore Membrane Protein POM 210; FLJ22389
Cat. No.: HY-P77109
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NUP210; Nuclear Pore Membrane Glycoprotein 210; nucleoporin 210; Pore Membrane Protein Of 210 KDa; POM210; Nuclear Pore Protein Gp210; KIAA0906; nucleoporin 210kDa; GP210; nucleoporin Nup210; Nuclear Envelope Pore Membrane Protein POM 210; FLJ22389
Species:
Source:
Cat. No.: HY-P82799A
Synonyms: NUP62L; nucleoporin-62 C-terminal-like protein
Cat. No.: HY-180654
CAS No.: 3110272-60-8
Target:
Domaines de recherche:
JWZ-8-103 is an orally active analog of PRLX-93936 (HY-119264) and a molecular glue targeting TRIM21. JWZ-8-103 increases the thermal stability of TRIM21. JWZ-8-103 promotes rapid and efficient interaction between TRIM21 and NUP98 (the apparent EC50 for ternary complex formation with the PRYSPRY domain of TRIM21 and the APD domain of NUP98 is approximately 20 μM), induces extensive ubiquitination and proteasomal degradation of numerous adjacent nucleoporins (NUPs, and thereby triggers cellular apoptosis. JWZ-8-103 can be used for the research of pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
