3110272-60-8
3110272-60-8
Chemical Structure
JWZ-8-103
- CAS No.: 3110272-60-8
- Formula:C21H22ClFN4O2
- Molecular Weight:416.88
InChIKey: IKQWOCVGRWGJLP-UHFFFAOYSA-N
SMILES: CCOC1=CC(Cl)=CC=C1N2C(C3=CC(F)=CC=C3N=C2CN4CCNCC4)=O
Biological Activity: JWZ-8-103 is an orally active PRLX-93936 (HY-119264) analog and TRIM21-targeting molecular glue. JWZ-8-103 increases the thermal stability of TRIM21. JWZ-8-103 promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC50 = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 has anti-cancer effects against pancreatic cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JWZ-8-103 | 98.04% | JWZ-8-103 is an orally active PRLX-93936 (HY-119264) analog and TRIM21-targeting molecular glue. JWZ-8-103 increases the thermal stability of TRIM21. JWZ-8-103 promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC50 = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 has anti-cancer effects against pancreatic cancer. | ||||||||||||||||||||
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References
- [1]. Yuan L, et al. Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex. Cancer Discov. 2025 Dec 2;15(12):2505-2529. [Content Brief]
- [2]. Steven M, et al. Trim21-targeted compounds and uses thereof. WO2025255442A1. WIPO (PCT). 2025-06-06.
Keywords
