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opsin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) Endogenous Metabolite (3)
By Research Areas:	Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136234

9-cis-β-Carotene 9Z β-Carotene	Endogenous Metabolite	Others
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus .

HY-116711

11-cis-Retinal 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde	Drug Derivative Endogenous Metabolite	Neurological Disease
11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model .

HY-124717

YC-001	Endogenous Metabolite	Others
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .

11-cis-Retinal 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Derivative Endogenous Metabolite
11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model .

YC-001	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .

Species:	Human (1) Rat (1)
Tag:	His (2)
Source:	E. coli Cell-free (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702398

	OPN1LW Protein, Human (Cell-Free, His) Long-wave-sensitive opsin 1; Red cone photoreceptor pigment; Red-sensitive opsin; ROP	Human	E. coli Cell-free
	OPN1LW protein, crucial for vision, is a vital element of visual pigments responsible for light absorption. The pigments consist of opsin, forming a covalent bond with cis-retinal. This molecular mechanism is indispensable for perceiving light stimuli in vision. OPN1LW Protein, Human (Cell-Free, His) is the recombinant human-derived OPN1LW protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P702401

	OPN4 Protein, Rat (Cell-Free, His) Melanopsin; opsin-4	Rat	E. coli Cell-free
	OPN4 Protein, a photoreceptor with affinity for cis-retinaldehydes, crucially mediates light responses like the pupillary reflex and photoentrainment. Its multifaceted role includes potential participation in optokinetic visual tracking response. Moreover, OPN4 may regulate retinal hyaloid vessel growth, emphasizing its significance in intricate aspects of ocular physiology. OPN4 Protein, Rat (Cell-Free, His) is the recombinant rat-derived OPN4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (1) Rat (1)
Application:	IHC-P (2) ICC/IF (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83524

	Rhodopsin Antibody (YA3269) CSNBAD1; OPN2; opsd; opsin 2 rod pigment; opsin2; Retinitis pigmentosa 4 autosomal dominant; RHO; Rhodopsin; RP4	WB, IHC-P	Human, Rat
	Rhodopsin Antibody (YA3269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rhodopsin.

HY-P83780

	OPN3 Antibody OPN3; ECPN; opsin-3; Encephalopsin; Panopsin	WB, IHC-P, ICC/IF	Human, Mouse
	OPN3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to OPN3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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