1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. YC-001

YC-001 

Cat. No.: HY-124717 Purity: 99.47%
Handling Instructions

YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration.

For research use only. We do not sell to patients.

YC-001 Chemical Structure

YC-001 Chemical Structure

CAS No. : 748778-73-6

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Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration[1].

IC50 & Target[1]

rod opsin

 

In Vitro

YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150–310%[1].
YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant[1].
YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC50 OF 0.98 µM[1].
YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: NIH3T3 cells
Concentration: 0.5, 1, 5, 10, 20, 40 µM
Incubation Time:
Result: Improved the glycosylation profile of P23H opsin.
In Vivo

YC-001 (50, 200mg/kg; i.p.) protects Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration[1].
YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods[1].
YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old Abca4 −/−Rdh8−/− mice[1]
Dosage: 50, 200mg/kg
Administration: I.P.
Result: Protected Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration.
Animal Model: C57BL/6 mouse[1]
Dosage: 200 mg/kg
Administration: I.P.
Result: Entered mouse eyes after systemic administration but is not retained for prolonged periods.
Animal Model: C57BL/6 mice[1]
Dosage: 100 mg/kg, 200 mg/kg
Administration: I.p.; daily, 24 days
Result: Showed no acute toxicity.
Molecular Weight

282.77

Formula

C12H7ClO2S2

CAS No.
SMILES

O=C1OCC(C2=CC=C(Cl)S2)=C1C3=CC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (353.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5364 mL 17.6822 mL 35.3644 mL
5 mM 0.7073 mL 3.5364 mL 7.0729 mL
10 mM 0.3536 mL 1.7682 mL 3.5364 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
YC-001
Cat. No.:
HY-124717
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