10 Results for "

p-GSK3

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "p-GSK3" in MCE Product Catalog:

Bisphenol F
Bisphenol F
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Cat. No.: HY-W014901
CAS No.: 620-92-8
Synonyms: BPF; 4,4'-Dihydroxydiphenylmethane
Category:  

Orchidaceae Galeola faberi Rolfe Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

Reactive Oxygen Species (ROS) Akt GSK-3 Apoptosis

Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) [3] .
Sodium thiosulfate (99%, water≤1.0%)
Sodium thiosulfate (99%, water≤1.0%)
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Cat. No.: HY-108775A
CAS No.: 7772-98-7
Purity:  99.89%
Synonyms: Sodium hyposulfite (99%, water≤1.0%)
Sodium thiosulfate (Sodium hyposulfite) is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease [3] .
Avenanthramide C
Avenanthramide C
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Cat. No.: HY-124344
CAS No.: 116764-15-9
Purity:  98.90%
Category:  

Avena sativa Linn. Simple Phenylpropanols Gramineae Phenylpropanoids Plants

Target:  

Interleukin Related

Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .
DM-PIT-1
DM-PIT-1
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Cat. No.: HY-124348
CAS No.: 701947-53-7
Synonyms: 3,5-Dimethyl PIT-1
Target:  

PI3K

Research Areas:  

Cancer

DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .
Bisphenol F-13C6
Bisphenol F-13C6
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Cat. No.: HY-W014901S
CAS No.: 1410794-06-7
Synonyms: BPF-13C6; 4,4'-Dihydroxydiphenylmethane-13C6
Bisphenol F- 13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) [3] .
Bisphenol F-13C12
Bisphenol F-13C12
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Cat. No.: HY-W014901S1
CAS No.: 1410794-08-9
Synonyms: BPF-13C12; 4,4'-Dihydroxydiphenylmethane-13C12
Bisphenol F- 13C12 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) [3] .
Nef-M1
Nef-M1
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Cat. No.: HY-P10971
CAS No.: 860401-80-5
Target:  

CXCR Apoptosis VEGFR GSK-3 Cadherin Caspase

Research Areas:  

Cancer

Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer .
Bisphenol F (Standard)
Bisphenol F (Standard)
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Cat. No.: HY-W014901R
CAS No.: 620-92-8
Synonyms: BPF (Standard); 4,4'-Dihydroxydiphenylmethane (Standard)
Category:  

Orchidaceae Galeola faberi Rolfe Phenols Polyphenols Plants

Target:  

Reference Standards Reactive Oxygen Species (ROS) Akt GSK-3 Apoptosis

Bisphenol F (Standard) is the analytical standard of Bisphenol F (HY-W014901). This product is intended for research and analytical applications. Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) [3] .
Sodium thiosulfate (98%)
Sodium thiosulfate (98%)
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Cat. No.: HY-108775
CAS No.: 7772-98-7
Synonyms: Sodium hyposulfite (98%)
Target:  

COX Interleukin Related NF-κB β-catenin GSK-3

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sodium thiosulfate (Sodium hyposulfite) is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease [3] .
Multitarget AD-IN-7
Multitarget AD-IN-7
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Cat. No.: HY-182788
CAS No.: 3113741-59-3
Target:  

GSK-3 Tau Protein Amyloid-β β-catenin

Research Areas:  

Neurological Disease

Multitarget AD-IN-7 is an orally active multi-target anti-AD compound. Multitarget AD-IN-7 exhibits inhibitory activity against GSK-3β and GSK-3α (IC50 = 0.66, 0.83 nM). Multitarget AD-IN-7 upregulates the expression of p-GSK-3β-Ser9, inhibits the phosphorylation of tau-Ser396, targets Aβ1-42, chelates pathogenic metal ions, scavenges ABTS•+, upregulates the expression of β-catenin and neurogenesis biomarkers, and promotes neurite outgrowth. Multitarget AD-IN-7 improves motor ability in Alzheimer's disease zebrafish. Multitarget AD-IN-7 is applicable to research related to Alzheimer's disease .
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