116764-15-9
Chemical Structure
Avenanthramide C
- CAS No.: 116764-15-9
- Formula:C16H13NO6
- Molecular Weight:315.28
IUPAC Name: (E)-2-(3-(3,4-dihydroxyphenyl)acrylamido)-5-hydroxybenzoic acid
InChIKey: IDUUXROOZBOOPH-QHHAFSJGSA-N
SMILES: O=C(C1=CC(O)=CC=C1NC(/C=C/C2=CC=C(C(O)=C2)O)=O)O
Biological Activity: Avenanthramide C is an orally active polyphenolic compound that penetrates the blood-brain barrier. Avenanthramide C is derived from oats. Avenanthramide C inhibits NF-κB nuclear translocation and inhibits the phosphorylation of PI3K, PLCγ1, Lyn, Syk, and Akt. Avenanthramide C inhibits the expression and activity of MMP-9 and inhibits MAPK phosphorylation. Avenanthramide C scavenges DPPH radicals, reduces intracellular ROS, and inhibits pro-inflammatory cytokine release and adhesion molecule expression. Avenanthramide C inhibits cell degranulation. Avenanthramide C attenuates active systemic anaphylaxis and inhibits passive cutaneous anaphylaxis. Avenanthramide C ameliorates PHZ-induced blood stasis. Avenanthramide C inhibits neuroinflammation, restores long-term potentiation, and improves recognition and spatial memory in Alzheimer's disease models. Avenanthramide C can be used for research on allergic inflammation, thrombosis, atherosclerosis, and Alzheimer's disease[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Avenanthramide C | 99.13% | Avenanthramide C is an orally active polyphenolic compound that penetrates the blood-brain barrier. Avenanthramide C is derived from oats. Avenanthramide C inhibits NF-κB nuclear translocation and inhibits the phosphorylation of PI3K, PLCγ1, Lyn, Syk, and Akt. Avenanthramide C inhibits the expression and activity of MMP-9 and inhibits MAPK phosphorylation. Avenanthramide C scavenges DPPH radicals, reduces intracellular ROS, and inhibits pro-inflammatory cytokine release and adhesion molecule expression. Avenanthramide C inhibits cell degranulation. Avenanthramide C attenuates active systemic anaphylaxis and inhibits passive cutaneous anaphylaxis. Avenanthramide C ameliorates PHZ-induced blood stasis. Avenanthramide C inhibits neuroinflammation, restores long-term potentiation, and improves recognition and spatial memory in Alzheimer's disease models. Avenanthramide C can be used for research on allergic inflammation, thrombosis, atherosclerosis, and Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Dhakal H, et al. Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells. Scientific reports. 2019 May 03;9(1):6884.
- [2]. Wang LW, et al. Avenanthramide C from underutilized oat glumes exhibits dual anti-oxidant and anti-thrombotic effects in oxidative damage and thrombosis models. Food & function. 2025 Jul 01;16(13):5380-5392.
- [3]. Park J, et al. Avenanthramide C Suppresses Matrix Metalloproteinase-9 Expression and Migration Through the MAPK/NF- κB Signaling Pathway in TNF-α-Activated HASMC Cells. Frontiers in pharmacology. 2021;12:621854.
- [4]. Matsukawa T, et al. Occurrence of avenanthramides and hydroxycinnamoyl-CoA:hydroxyanthranilate N-hydroxycinnamoyltransferase activity in oat seeds. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2000;55(1-2):30-6. [Content Brief]
- [5]. Ramasamy VS, et al. Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer's Disease Model Mice. Molecular neurobiology. 2020 Jan;57(1):315-330. [Content Brief]
