Cat. No.: HY-108775

Sodium thiosulfate (98%)

(Synonyms: Sodium hyposulfite (98%))

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Based on 1 Customer Validation

Sodium thiosulfate (Sodium hyposulfite) is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease.

For research use only. We do not sell to patients.

Purity: 98.30%
CAS No.: 7772-98-7
Formula: Na₂S₂O₃
Molecular Weight:158.11

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Sodium thiosulfate (98%) Chemical Structure

CAS No.: 7772-98-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All COX Isoforms :

All NF-κB Isoforms :

All Interleukin Related Isoforms :

All GSK-3 Isoforms :

In Vitro

Sodium thiosulfate (1.2-120 μM; 48 h) does not affect MCF-7 viability^[1].
Sodium thiosulfate (3 mM; 8 h) stimulates proliferation of human umbilical vein endothelial cells (HUVEC)^[2].
Sodium thiosulfate (0.2-25 mM; 1-7 days) dose-dependently inhibits mineralization of murine joint chondrocytes^[3].
Sodium thiosulfate (1-500 μM; 8 h) reduces LPS/IFNγ-induced release of TNFα and IL-6 in microglia^[4].
Sodium thiosulfate (0.1-10 mM; 48 h) does not attenuate the anticancer activity of Doxorubicin (HY-15142A) in human breast cancer MCF-7 cells and human cervical cancer HeLa cells^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium thiosulfate (0.5-1 g/kg/day; p.o. via water bottle; changed three times a week) promotes hindlimb ischemia-induced revascularization and muscle recovery in WT C57BL/6JRj mice and hypercholesterolemic LDLR^-/- mice, increases capillary density, reduces muscle damage^[2].
Sodium thiosulfate (0.4 g/kg; i.p.; three times per week) reduces the volume and crystal content of new periarticular calcific deposits, attenuates tibial and femoral cartilage damage and proteoglycan loss, and shows a significant positive correlation between the volume of new mineralized structures and tibial cartilage degradation score in menisectomy-induced osteoarthritis model of female C57BL/6 mice^[3].
Sodium thiosulfate (2 g/kg; intraperitoneal injection, 0 and 12 h after LPS challenge; 0.5 g/kg; i.v., 10 min after CLP) attenuates LPS or CLP-induced acute lung injury in male C57BL6J mice by inhibiting lung inflammation, reducing lung permeability, and suppressing NFκB activation^[5].
Sodium thiosulfate (2-3 g/kg; once daily) inhibits tumor growth and EMT process by the Wnt/β-catenin signaling pathway in nude mice xenografted with B16 cells^[8].
Sodium thiosulfate (100-750 mg/kg; i.p.) reduces brain inflammation induced by systemic lipopolysaccharide administration in female C57BL/6J mice by decreasing IL-1β, COX-2, Iba-1, and TSPO levels ^[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7772-98-7
Appearance Solid
Molecular Weight 158.11
Formula Na₂S₂O₃
Color White to off-white
SMILES

[Na][Na].O=S(=O)=S=O
Synonyms

Sodium hyposulfite (98%)
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (632.47 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.3247 mL

31.6236 mL

63.2471 mL

5 mM

1.2649 mL

6.3247 mL

12.6494 mL

10 mM

0.6325 mL

3.1624 mL

6.3247 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ota A, et al. The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death. Pharmacol Rep. 2021 Jun;73(3):847-857. [Content Brief]

[2]. Macabrey D, et al. Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization. Front Cardiovasc Med. 2022 Oct 3;9:965965. [Content Brief]

[3]. Nasi S, et al. Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis. PLoS One. 2016 Jul 8;11(7):e0158196. [Content Brief]

[4]. Lee M, et al. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J Neuroinflammation. 2016 Feb 8;13:32. [Content Brief]

[5]. Sakaguchi M, et al. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology. 2014 Dec;121(6):1248-57. [Content Brief]

[6]. Mizuta Y, et al. Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice. Life Sci. 2020 Sep 15;257:118074. [Content Brief]

[7]. Bijarnia RK, et al. Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric rats. PLoS One. 2015 Apr 30;10(4):e0124881. [Content Brief]

[8]. Wang D, et al. Sodium thiosulfate inhibits epithelial-mesenchymal transition in melanoma via regulating the Wnt/β-catenin signaling pathway. J Dermatol Sci. 2023 Feb;109(2):89-98. [Content Brief]

[9]. Acero G, et al. Sodium thiosulphate attenuates brain inflammation induced by systemic lipopolysaccharide administration in C57BL/6J mice. Inflammopharmacology. 2017 May 19. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.3247 mL	31.6236 mL	63.2471 mL	158.1178 mL
	5 mM	1.2649 mL	6.3247 mL	12.6494 mL	31.6236 mL
	10 mM	0.6325 mL	3.1624 mL	6.3247 mL	15.8118 mL
	15 mM	0.4216 mL	2.1082 mL	4.2165 mL	10.5412 mL
	20 mM	0.3162 mL	1.5812 mL	3.1624 mL	7.9059 mL
	25 mM	0.2530 mL	1.2649 mL	2.5299 mL	6.3247 mL
	30 mM	0.2108 mL	1.0541 mL	2.1082 mL	5.2706 mL
	40 mM	0.1581 mL	0.7906 mL	1.5812 mL	3.9529 mL
	50 mM	0.1265 mL	0.6325 mL	1.2649 mL	3.1624 mL
	60 mM	0.1054 mL	0.5271 mL	1.0541 mL	2.6353 mL
	80 mM	0.0791 mL	0.3953 mL	0.7906 mL	1.9765 mL
	100 mM	0.0632 mL	0.3162 mL	0.6325 mL	1.5812 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium thiosulfate (98%)

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All COX Isoforms

All NF-κB Isoforms

All Interleukin Related Isoforms

All GSK-3 Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table