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Results for "

p97 ATPase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	p97 (13) ATP Synthase (2)
By Research Areas:	Cancer (13)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: p97 Na+/K+ ATPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12861

CB-5083 Maximum Cited Publications 47 Publications Verification	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the **p97 AAA ATPase*/VCP*. CB-5083 selectively inhibits p97 through its D2 site with the IC₅₀ of 11 nM .

HY-19795

ML240 5 Publications Verification	p97	Cancer
ML240 is a potent *p97* inhibitor, inhibiting p97 ATPase with IC₅₀ value of 100 nM.

HY-123872

MSC1094308 1 Publications Verification	p97	Cancer
MSC1094308 is a non-competitive and reversible *VPS4B/p97* (VCP)** (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and *p97, respectively . MSC1094308 inhibits the D2 ATPase* activity by binding to a agentable hotspot of *p97*. MSC1094308 can be used in study of cancer .

HY-19797A

ML241 hydrochloride	p97	Cancer
ML241 hydrochloride is a potent *p97* inhibitor, inhibiting p97 ATPase with IC₅₀ value of 100 nM.

HY-19797

ML241	p97	Cancer
ML241 is a potent, selective and competitive **p97 ATPase inhibitor with an IC₅₀** of 0.11 μM. ML241 can be used for the research of cancer .

HY-124776

NPD8733	p97	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

HY-179257

p97-IN-2	p97	Cancer
p97-IN-2 (Compound 14) is a **p97 ATPase (IC₅₀** = 0.6 μM) inhibitor. p97-IN-2 can inhibit cell proliferation, such as HCT15 (IC₅₀ = 1.1 μM) and SW403 (IC₅₀ = 0.8 μM) cells. p97-IN-2 can be used for cancer research .

HY-168005

NSC799462	p97 ATP Synthase	Cancer
NSC799462 is a triazole inhibitor of **p97 ATPase. NSC799462 inhibits p97 ATPase activity (IC₅₀ = 15 nM) by binding to a specific site on p97 and causing local changes in the p97** structure .

HY-19795R

ML240 (Standard)	p97	Cancer
ML240 (Standard) is the analytical standard of ML240. This product is intended for research and analytical applications. ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.

HY-168006

NSC819701	p97 ATP Synthase	Cancer
NSC819701 is a triazole inhibitor of the **p97 ATPase. NSC819701 inhibits the activity of p97 ATPase by binding to a specific site of p97** .

HY-124253

SMDC818909	p97	Cancer
SMDC818909 is an indole amide-derived uncompetitive inhibitor targeting **p97 AAA+ ATPase, with an IC₅₀ of 3.5 μM and a K_a** of 9.1 μM. SMDC818909 binds to the D2 ATPase domain of p97, preferentially associates with the ADP-bound conformation of p97, allosterically blocks the ATP hydrolysis cycle of p97, and inhibits its mediated intracellular protein homeostasis regulatory function. SMDC818909 is applied to the research and development of p97-targeted antitumor drugs, as well as studies on cancer-related proteotoxic stress mechanisms .

HY-118460

ACJI-99C VCP/p97-IN-PPA	p97	Cancer
ACJI-99C (VCP/p97-IN-PPA) is a selective covalent *p97/VCP* ATPase inhibitor with an IC₅₀ value of 0.6 μM. ACJI-99C binds with p97 active site residues to block ATPase activity. ACJI-99C irreversibly blocks degradation of p97-dependent protein in cells. ACJI-99C inhibits proliferation of cancer cells, including p97 inhibitor-resistant lines. ACJI-99C can be used for the research of colorectal cancer .

HY-125472

LC-1028	p97	Cancer
LC-1028 (Compound 20) is an irreversible, non-competitive, covalent p97 inhibitor with a Ki ^app value of 33.2 nM. LC-1028 covalently modifies the cysteine residues (Cys105, Cys522, Cys535) of p97. LC-1028 can be used in the research of pancreatic cancer .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705508

	VCP Protein, Human (sf9, GST) Transitional Endoplasmic Reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 Subunit; Valosin-Containing Protein; VCP	Human	Sf9 insect cells
	VCP proteins are indispensable for Golgi stack dynamics, coordinating fragmentation during mitosis and postmitotic reorganization. It actively promotes the formation of the transitional endoplasmic reticulum (tER), enables ATP-dependent vesicle budding, and enables membrane transfer to the Golgi apparatus. VCP Protein, Human (sf9, GST) is the recombinant human-derived VCP protein, expressed by Sf9 insect cells , with N-GST labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) IHC-F (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P82630

	VCP Antibody (YA2375) 15S Mg(2+) ATPase p97 subunit; ALS14; ATPase p97; CDC48; IBMPFD; p97; TER ATPase; TERA; VCP; Yeast Cdc48p homolog	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	VCP Antibody (YA2375) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VCP.

HY-P82630A

	VCP Antibody (YA2375)(PBS only) 15S Mg(2+) ATPase p97 subunit; ALS14; ATPase p97; CDC48; IBMPFD; p97; TER ATPase; TERA; VCP; Yeast Cdc48p homolog	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	VCP Antibody (YA2375) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VCP.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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