1542705-92-9
1542705-92-9
Chemical Structure
CB-5083
- CAS No.: 1542705-92-9
- Formula:C24H23N5O2
- Molecular Weight:413.47
IUPAC Name: 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
InChIKey: RDALZZCKQFLGJP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(COCC5)C5=N3)N
Biological Activity: CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM[1].
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CB-5083 | 99.90% | CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM. | ||||||||||||||||||||
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CB-5083 (Standard) | ≥98% | CB-5083 (Standard) is the analytical standard of CB-5083 (HY-12861). This product is intended for research and analytical applications. CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.79
HY-183920LC-1310 -
Similarity Score 0.77
HY-128724CB-5339 -
Similarity Score 0.71
HY-174847VCP/p97 IN-2 -
Similarity Score 0.70
HY-174844p97-IN-1 -
Similarity Score 0.67
HY-125472LC-1028 -
Similarity Score 0.60
HY-139606VCP/p97 inhibitor-1 -
Similarity Score 0.53
HY-19797AML241 hydrochloride -
Similarity Score 0.53
HY-19795RML240 (Standard) -
Similarity Score 0.53
HY-19797ML241 -
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