1135195-64-0
Chemical Structure
ACJI-99C
Synonym(s): VCP/p97-IN-PPA
- CAS No.: 1135195-64-0
- Formula:C18H19N5O
- Molecular Weight:321.38
IUPAC Name: N-(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)acrylamide
InChIKey: MAVSQZRQGSMPPT-UHFFFAOYSA-N
SMILES: O=C(C=C)NC1=NC=NC2=C1C(=NN2C(C)(C)C)C=3C=CC=CC3
Biological Activity: ACJI-99C (VCP/p97-IN-PPA) is a selective covalent p97/VCP ATPase inhibitor with an IC50 value of 0.6 μM. ACJI-99C binds with p97 active site residues to block ATPase activity. ACJI-99C irreversibly blocks degradation of p97-dependent protein in cells. ACJI-99C inhibits proliferation of cancer cells, including p97 inhibitor-resistant lines. ACJI-99C can be used for the research of colorectal cancer[1].
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ACJI-99C | ACJI-99C (VCP/p97-IN-PPA) is a selective covalent p97/VCP ATPase inhibitor with an IC50 value of 0.6 μM. ACJI-99C binds with p97 active site residues to block ATPase activity. ACJI-99C irreversibly blocks degradation of p97-dependent protein in cells. ACJI-99C inhibits proliferation of cancer cells, including p97 inhibitor-resistant lines. ACJI-99C can be used for the research of colorectal cancer. | |||||||||||||||||||||
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Keywords
