2324158-08-7
2324158-08-7
Chemical Structure
LC-1028
- CAS No.: 2324158-08-7
- Formula:C28H27N5O
- Molecular Weight:449.55
IUPAC Name: N-(1-(4-(benzylamino)-5,6,7,8-tetrahydroquinazolin-2-yl)-2-methyl-1H-indol-4-yl)but-2-ynamide
InChIKey: YOUVOKAIDVNCJA-UHFFFAOYSA-N
SMILES: CC#CC(NC1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C5CCCCC5=N3)=O
Biological Activity: LC-1028 (Compound 20) is an irreversible, non-competitive, covalent p97 inhibitor with a Kiapp value of 33.2 nM. LC-1028 covalently modifies the cysteine residues (Cys105, Cys522, Cys535) of p97. LC-1028 can be used in the research of pancreatic cancer[1].
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LC-1028 | LC-1028 (Compound 20) is an irreversible, non-competitive, covalent p97 inhibitor with a Kiapp value of 33.2 nM. LC-1028 covalently modifies the cysteine residues (Cys105, Cys522, Cys535) of p97. LC-1028 can be used in the research of pancreatic cancer. | |||||||||||||||||||||
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References
Keywords
