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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
pain perception
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "pain perception" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: Lysine vasopressin; [Lys8]-Vasopressin
2
2 Cited Publications
Cat. No.: HY-P0004A
CAS No.: 83968-49-4
Synonyms: Lysine vasopressin acetate; [Lys8]-Vasopressin acetate
Research Areas:
1
1 Cited Publications
Synonyms: Arachidonyl-2-chloroethylamide
Cat. No.: HY-110302
CAS No.: 2410327-94-3
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6'-GNTI dihydrochloride, a κ-opioid receptor (KOR) agonist, displays bias toward the activation of G protein-mediated signaling over β-arrestin2 recruitment. 6'-GNTI 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neurons .
Cat. No.: HY-P10654
CAS No.: 2861260-80-0
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Cat. No.: HY-121947
CAS No.: 80749-33-3
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1'-Naphthoyl-2-methylindole (Compound 88) is a cannabinoid mimetics and an inhibitor for Win 55212-2, that inhibits 34% of [3H]Win 55212-2 binding to cannabinoid receptors at 3 μM .
Cat. No.: HY-138985
CAS No.: 22913-17-3
Synonyms: Santinamide
Category:
Target:
Cat. No.: HY-14753
CAS No.: 861151-12-4
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Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder .
Cat. No.: HY-167862
CAS No.: 2411412-36-5
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UCM-05194 is a selective LPA1 receptor agonist with activity to improve neuropathic pain. UCM-05194 is a LPA1 agonist that exhibits potent and selective properties in its pharmacologically similar properties. UCM-05194 triggers LPA1-mediated cellular effects and leads to internalization of the receptor, resulting in functional inactivation in primary sensory neurons. UCM-05194 effectively reduces pain perception in in vivo models. UCM-05194 can be used to conduct research on progressive systemic diseases .
Cat. No.: HY-141468
CAS No.: 67025-98-3
Synonyms: β-CNA dihydrochloride
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β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception .
Cat. No.: HY-163895
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δ opioid receptor antagonist 1 (compound 6-Cy3) is a fluorescent antagonist probe with high selectivity for δ opioid receptor (DOR) (Ki=1.7 nM). δ opioid receptor antagonist 1 can be used to study the mechanism of pain perception .
Cat. No.: HY-P3517
CAS No.: 77761-27-4
Synonyms: β-EP (6-31), human
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Cat. No.: HY-158362A
CAS No.: 9040-75-9
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Monoglyceride lipase, Bacillus sp., is a key enzyme involved in lipid metabolism. It catalyzes the hydrolysis of monoglycerides (particularly 2-AG, or 2-arachidonoylglycerol) into glycerol and free fatty acids. By regulating the levels of 2-AG, Monoglyceride lipase, Bacillus sp., can influence neural signaling, pain perception, inflammatory responses, and metabolic processes .
Synonyms: Lysine vasopressin (Standard); [Lys8]-Vasopressin (Standard)
Category:
Cat. No.: HY-W424876
CAS No.: 6034-68-0
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N-(7H-Purin-6-yl)acetamide (Compound 25) is a selective adenosine receptor (AdeR) agonist with a Ki value of 0.515 μM for the human adenosine receptor and a Ki value of 2.85 μM for the rat adenosine receptor. N-(7H-Purin-6-yl)acetamide is promising for research of adenosine receptor function, pain perception, inflammatory responses, and renal function .
Cat. No.: HY-L923
9000 compounds
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields.
MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
