83968-49-4
Chemical Structure
Lysipressin acetate
Synonym(s): Lysine vasopressin acetate; [Lys8]-Vasopressin acetate
- CAS No.: 83968-49-4
- Formula:C48H69N13O14S2
- Molecular Weight:1116.27
IUPAC Name: (S)-N-((S)-6-amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide acetate
InChIKey: NKWAIKZITYLOMT-DHSVNZEYSA-N
SMILES: O=C(N1CCC[C@H]1C(N[C@H](C(NCC(N)=O)=O)CCCCN)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@]([H])(CC2=CC=CC=C2)N3)=O)=O)=O)CSSC[C@H](N)C(N[C@@H](CC4=CC=C(C=C4)O)C3=O)=O.OC(C)=O
Biological Activity: Lysipressin acetate (Lysine vasopressin acetate; [Lys8]-Vasopressin acetate) is a neurohypophyseal nonapeptide with dual cardiovascular regulatory activities of peripheral pressor action and central hypotensive action, and it also regulates pain perception in the body. Lysipressin acetate is an Oxytocin Receptor agonist, with a Ki value of 10.2 nM for porcine OT receptor. Lysipressin acetate stimulates contraction of rabbit bladder smooth muscle via V1-vasopressin receptor. The central hypotensive effect of Lysipressin acetate depends on the sympathetic tone pathway. Lysipressin acetate dose-dependently prolongs tail-flick latency in rats, producing a stable central antinociceptive effect. Lysipressin acetate can be used in studies related to cardiovascular regulation, hypertension and pain[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Lysipressin acetate | 99.81% | Lysipressin acetate (Lysine vasopressin acetate; [Lys8]-Vasopressin acetate) is a neurohypophyseal nonapeptide with dual cardiovascular regulatory activities of peripheral pressor action and central hypotensive action, and it also regulates pain perception in the body. Lysipressin acetate is an Oxytocin Receptor agonist, with a Ki value of 10.2 nM for porcine OT receptor. Lysipressin acetate stimulates contraction of rabbit bladder smooth muscle via V1-vasopressin receptor. The central hypotensive effect of Lysipressin acetate depends on the sympathetic tone pathway. Lysipressin acetate dose-dependently prolongs tail-flick latency in rats, producing a stable central antinociceptive effect. Lysipressin acetate can be used in studies related to cardiovascular regulation, hypertension and pain. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Yu H, et al. Lysine Vasopressin-Induced Increases in Porcine Myometrial Contractility and Intracellular Ca²⁺ Concentrations of Myometrial Cells: Involvement of Oxytocin Receptors. Biology of Reproduction, 1995, 52: 584-590. [Content Brief]
- [2]. Crankshaw D, et al. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle. European journal of pharmacology. 1989 Dec 07;173(2-3):183-8. [Content Brief]
- [3]. Tran LD, et al. Effects of lysine-vasopressin and oxytocin on central cardiovascular control. British journal of pharmacology. 1982 Sep;77(1):69-73. [Content Brief]
- [4]. Kordower JH, et al. Central antinociceptive effects of lysine-vasopressin and an analogue. Peptides. 1982;3(4):613-7. [Content Brief]
Keywords
