1. GPCR/G Protein
  2. Vasopressin Receptor
  3. Felypressin

Felypressin  (Synonyms: PLV-2)

Cat. No.: HY-A0182
Handling Instructions

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Felypressin Chemical Structure

Felypressin Chemical Structure

CAS No. : 56-59-7

Size Price Stock
Solution
10 mM * 1 mL in DMSO USD 137 Ask For Quote & Lead Time
Solid
2 mg USD 60 Ask For Quote & Lead Time
5 mg USD 84 Ask For Quote & Lead Time
10 mg USD 120 Ask For Quote & Lead Time
50 mg USD 216 Ask For Quote & Lead Time
100 mg USD 264 Ask For Quote & Lead Time

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Description

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures[1][2].

IC50 & Target

Vasopressin 1[2]

In Vitro

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure[1].
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1040.22

Formula

C46H65N13O11S2

CAS No.
Sequence

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10.4 mg/mL (10.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9613 mL 4.8067 mL 9.6134 mL
5 mM 0.1923 mL 0.9613 mL 1.9227 mL
10 mM 0.0961 mL 0.4807 mL 0.9613 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Felypressin
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HY-A0182
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