1. GPCR/G Protein
  2. Vasopressin Receptor
  3. Felypressin

Felypressin (Synonyms: PLV-2)

Cat. No.: HY-A0182 Purity: 99.68%
Handling Instructions

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.

For research use only. We do not sell to patients.

Felypressin Chemical Structure

Felypressin Chemical Structure

CAS No. : 56-59-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 137 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 264 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures[1][2].

IC50 & Target

Vasopressin 1[2]

In Vitro

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells[1].

In Vivo

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure[1].
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors[2].

Clinical Trial
Molecular Weight

1040.22

Formula

C₄₆H₆₅N₁₃O₁₁S₂

CAS No.

56-59-7

Sequence

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)

SMILES

O=C([[email protected]](CSSC[[email protected]@H](C(N[[email protected]](C1=O)CC2=CC=CC=C2)=O)N)NC([[email protected]@H](NC([[email protected]@H](NC([[email protected]](N1)([H])CC3=CC=CC=C3)=O)CCC(N)=O)=O)CC(N)=O)=O)N(CCC4)[[email protected]@H]4C(N[[email protected]@H](CCCCN)C(NCC(N)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10.4 mg/mL (10.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9613 mL 4.8067 mL 9.6134 mL
5 mM 0.1923 mL 0.9613 mL 1.9227 mL
10 mM 0.0961 mL 0.4807 mL 0.9613 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

FelypressinPLV-2PLV2PLV 2Vasopressin ReceptorVasopressin 1vasoconstrictorhormonepituitaryanestheticdentalnon-catecholamineArginineInhibitorinhibitorinhibit

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