2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. β-Endorphin (6-31), human

β-Endorphin (6-31), human  (Synonyms: β-EP (6-31), human)

Cat. No.: HY-P3517
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β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.

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β-Endorphin (6-31), human Chemical Structure

β-Endorphin (6-31), human Chemical Structure

CAS No. : 77761-27-4

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β-Endorphin (6-31), human Related Antibodies

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Description

β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation[1].

In Vivo

β-Endorphin (0.03 to 1.00 μg/kg, i.p., once) impairs retention of a one-trial inhibitory avoidance task in a dose-dependent manner in male Swiss mice immediately post-training. Also, it works in the process of memory consolidation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Swiss mice (22-25 g)[1]
Dosage: 0.03, 0.10, 0.30 or 1.00 μg/kg
Administration: i.p., once
Result: Significantly impaired retention at the doses of 0.03 and 0.10 μg/kg while not significantly affect retention as compared with the control group at the two higher doses of 0.30 and 1.00 μg/kg , but tended to increase retention as compared with the dose of 0.10 μg/kg.
Increased latencies to step-through at the two higher doses of 0.30 and 1.00 μg/kg but no effect at lower doses.
Molecular Weight

2909.38

Formula

C131H218N34O40
CAS No.
Sequence

Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
Sequence Shortening

TSEKSQTPLVTLFKNAIIKNAYKKGE
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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β-Endorphin (6-31), human Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Endorphin (6-31), human77761-27-4β-EP (6-31), humanOpioid Receptoropioid neuropeptideopioid receptorreduce stresshomeostasispain perception regulationInhibitorinhibitorinhibit

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