2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Rosonabant

Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder.

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Rosonabant

Rosonabant Chemical Structure

CAS No. : 861151-12-4

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Based on 1 publication(s) in Google Scholar

Rosonabant Related Antibodies

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Description

Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder[1].

Molecular Weight

451.78

Formula

C21H21Cl3N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C2CC(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C=C4Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (132.81 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2135 mL 11.0673 mL 22.1347 mL
5 mM 0.4427 mL 2.2135 mL 4.4269 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2135 mL 11.0673 mL 22.1347 mL 55.3367 mL
5 mM 0.4427 mL 2.2135 mL 4.4269 mL 11.0673 mL
10 mM 0.2213 mL 1.1067 mL 2.2135 mL 5.5337 mL
15 mM 0.1476 mL 0.7378 mL 1.4756 mL 3.6891 mL
20 mM 0.1107 mL 0.5534 mL 1.1067 mL 2.7668 mL
25 mM 0.0885 mL 0.4427 mL 0.8854 mL 2.2135 mL
30 mM 0.0738 mL 0.3689 mL 0.7378 mL 1.8446 mL
40 mM 0.0553 mL 0.2767 mL 0.5534 mL 1.3834 mL
50 mM 0.0443 mL 0.2213 mL 0.4427 mL 1.1067 mL
60 mM 0.0369 mL 0.1845 mL 0.3689 mL 0.9223 mL
80 mM 0.0277 mL 0.1383 mL 0.2767 mL 0.6917 mL
100 mM 0.0221 mL 0.1107 mL 0.2213 mL 0.5534 mL
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Rosonabant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosonabant861151-12-4Cannabinoid Receptorobesityselectivepain perceptionnauseamental disorderInhibitorinhibitorinhibit

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